Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 73546..74077 Replicon plasmid unnamed1
Accession NZ_CP038899
Organism Piscirickettsia salmonis strain Psal-006b

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag Psal006b_RS16690 Protein ID WP_027243212.1
Coordinates 73790..74077 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag Psal006b_RS16685 Protein ID WP_027243211.1
Coordinates 73546..73800 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal006b_RS16655 69271..70251 + 981 WP_144420849.1 hypothetical protein -
Psal006b_RS16660 70333..70677 - 345 Protein_94 DDE-type integrase/transposase/recombinase -
Psal006b_RS16665 70717..71694 - 978 WP_036771347.1 IS5 family transposase -
Psal006b_RS16670 71890..72078 + 189 Protein_96 hypothetical protein -
Psal006b_RS16675 72175..73152 + 978 WP_036771347.1 IS5 family transposase -
Psal006b_RS16680 73167..73328 + 162 WP_155046636.1 hypothetical protein -
Psal006b_RS16685 73546..73800 + 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Psal006b_RS16690 73790..74077 + 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Psal006b_RS16695 74084..74545 - 462 Protein_101 tail assembly protein -
Psal006b_RS16700 74572..75549 - 978 WP_036771347.1 IS5 family transposase -
Psal006b_RS16705 75661..76683 + 1023 WP_027243215.1 hypothetical protein -
Psal006b_RS16710 76756..77097 + 342 Protein_104 IS6 family transposase -
Psal006b_RS16715 77166..77894 - 729 WP_036774350.1 IS6 family transposase -
Psal006b_RS16720 77964..78569 + 606 Protein_106 IS982 family transposase -
Psal006b_RS16725 78852..79022 + 171 Protein_107 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..186370 186370


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T123348 WP_027243212.1 NZ_CP038899:73790-74077 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T123348 NZ_CP038899:73790-74077 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT123348 WP_027243211.1 NZ_CP038899:73546-73800 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT123348 NZ_CP038899:73546-73800 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References