Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 33925..34483 Replicon plasmid unnamed3
Accession NZ_CP038896
Organism Piscirickettsia salmonis strain Psal-006a

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Psal006a_RS18115 Protein ID WP_155047328.1
Coordinates 34271..34483 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag Psal006a_RS18110 Protein ID WP_155047327.1
Coordinates 33925..34278 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Psal006a_RS18085 29471..29770 - 300 WP_016210976.1 hypothetical protein -
Psal006a_RS18090 29924..30229 - 306 WP_016210958.1 hypothetical protein -
Psal006a_RS18660 30489..30641 - 153 WP_162034504.1 hypothetical protein -
Psal006a_RS18095 30898..31653 + 756 WP_016210971.1 methyltransferase domain-containing protein -
Psal006a_RS18100 31730..32455 + 726 WP_016210975.1 ester cyclase -
Psal006a_RS18105 32476..33855 - 1380 WP_155047326.1 MFS transporter -
Psal006a_RS18110 33925..34278 - 354 WP_155047327.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Psal006a_RS18115 34271..34483 - 213 WP_155047328.1 type II toxin-antitoxin system HicA family toxin Toxin
Psal006a_RS18120 34527..35501 - 975 WP_054300271.1 IS30 family transposase -
Psal006a_RS18125 35861..36190 - 330 WP_155047329.1 hypothetical protein -
Psal006a_RS18130 36648..36887 + 240 WP_080963666.1 transposase zinc-binding domain-containing protein -
Psal006a_RS18135 36812..37774 + 963 WP_036773142.1 IS91 family transposase -
Psal006a_RS18140 38100..39146 + 1047 WP_027243195.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..39810 39810


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-66)

Antitoxin

Uncharacterised protein family HicB

(53-103)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7691.99 Da        Isoelectric Point: 10.5676

>T123344 WP_155047328.1 NZ_CP038896:c34483-34271 [Piscirickettsia salmonis]
IKASIVWADIEKLLLALGAEVIERDGSRVAVILNQVKTTFHRPHPEKTTDKGAVKSIRLFLKNAGVDKNA

Download         Length: 213 bp

>T123344 NZ_CP038896:c34483-34271 [Piscirickettsia salmonis]
ATCAAAGCAAGCATTGTTTGGGCTGATATAGAAAAGCTTCTTTTAGCGTTAGGGGCTGAAGTAATAGAGCGTGATGGTTC
AAGGGTTGCTGTCATTTTGAATCAAGTGAAAACAACATTTCATAGACCGCACCCTGAAAAAACAACAGACAAGGGGGCGG
TTAAGTCAATAAGGTTGTTTTTAAAAAATGCTGGAGTAGATAAAAATGCTTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13476.43 Da        Isoelectric Point: 5.0200

>AT123344 WP_155047327.1 NZ_CP038896:c34278-33925 [Piscirickettsia salmonis]
MLKYKGYIGKVEEIHEGDEYIYGIVPNIKDVISFKGKNIKELTKDFKLAIDDYLALCDEREEEPDKPFSGRFMTRLGSDL
HEEVFLASMNDSGAKSMNDWVVSACLEKLKHDQIVKR

Download         Length: 354 bp

>AT123344 NZ_CP038896:c34278-33925 [Piscirickettsia salmonis]
ATGCTTAAATACAAAGGTTATATTGGAAAAGTTGAAGAGATTCATGAAGGTGATGAATATATTTATGGGATTGTTCCAAA
TATTAAAGATGTTATTTCTTTTAAAGGTAAAAATATAAAAGAGTTAACGAAAGACTTTAAGCTGGCTATTGATGATTATT
TGGCTTTATGTGATGAGCGTGAAGAAGAACCCGATAAACCATTTTCTGGTAGATTTATGACTAGATTAGGTAGTGATTTG
CATGAAGAGGTTTTTTTAGCTTCTATGAATGATTCAGGTGCAAAATCAATGAATGATTGGGTTGTATCTGCATGCTTGGA
AAAGTTGAAGCATGATCAAATCGTTAAACGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References