Detailed information of TA system TA123337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 53976..54507
• Replicon: plasmid unnamed2
• Accession: NZ_CP038888
• Organism: Piscirickettsia salmonis strain Psal-004

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Psal004_RS17415
• Protein ID: WP_016210662.1
• Coordinates: 53976..54263 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Psal004_RS17420
• Protein ID: WP_016210670.1
• Coordinates: 54253..54507 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Psal004_RS17380	48977..49300	+	324	WP_032126913.1	hypothetical protein	-
Psal004_RS17385	49357..49623	+	267	WP_016211142.1	DUF4035 domain-containing protein	-
Psal004_RS17390	49627..51705	+	2079	WP_032126912.1	hypothetical protein	-
Psal004_RS17395	51698..52039	+	342	WP_016210657.1	phage tail protein	-
Psal004_RS17400	52036..52707	+	672	WP_016210666.1	phage minor tail protein L	-
Psal004_RS17405	52676..53422	+	747	WP_032126911.1	C40 family peptidase	-
Psal004_RS17410	53412..53969	+	558	WP_016210665.1	tail assembly protein	-
Psal004_RS17415	53976..54263	-	288	WP_016210662.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Psal004_RS17420	54253..54507	-	255	WP_016210670.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
Psal004_RS17425	54601..57888	+	3288	WP_016210653.1	host specificity protein J	-
Psal004_RS17430	57888..59027	+	1140	WP_032126910.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..79944	79944

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-55)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11064.15 Da
• Isoelectric Point: 10.7358

>T123337 WP_016210662.1 NZ_CP038888:c54263-53976 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKEDKVVVQVLAIG
SRNRLEAYRLAASRL

Nucleotide

• Length: 288 bp

>T123337 NZ_CP038888:c54263-53976 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAGAGGATAAAGTGGTTGTTCAAGTCTTGGCGATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9450.69 Da
• Isoelectric Point: 4.0808

>AT123337 WP_016210670.1 NZ_CP038888:c54507-54253 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNAPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLNSPDCDFIDVD
VDDL

Nucleotide

• Length: 255 bp

>AT123337 NZ_CP038888:c54507-54253 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACCATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATTAATGAAGCCAA
CGGCGAGCCGGTGGTTATTTTGAATCATAATGCTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTGAATTCTCCTGATTGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA