Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2024948..2025522 Replicon chromosome
Accession NZ_CP038874
Organism Pasteurella multocida strain FCf76

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E5136_RS09585 Protein ID WP_061406134.1
Coordinates 2024948..2025232 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag E5136_RS09590 Protein ID WP_061406133.1
Coordinates 2025229..2025522 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5136_RS09565 2020741..2022330 - 1590 WP_081106270.1 AAA family ATPase -
E5136_RS09570 2022615..2023166 - 552 WP_196766247.1 NERD domain-containing protein -
E5136_RS09575 2023310..2023669 + 360 WP_095261631.1 DUF3418 domain-containing protein -
E5136_RS09585 2024948..2025232 + 285 WP_061406134.1 hypothetical protein Toxin
E5136_RS09590 2025229..2025522 + 294 WP_061406133.1 putative addiction module antidote protein Antitoxin
E5136_RS09595 2025925..2026602 - 678 WP_005726756.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
E5136_RS09600 2026620..2027087 - 468 WP_064661066.1 PTS sugar transporter subunit IIA -
E5136_RS09605 2027132..2028922 - 1791 WP_061406132.1 PTS ascorbate-specific subunit IIBC -
E5136_RS09610 2029272..2030363 + 1092 WP_005751571.1 L-ascorbate 6-phosphate lactonase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-87)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10667.40 Da        Isoelectric Point: 10.2297

>T123325 WP_061406134.1 NZ_CP038874:2024948-2025232 [Pasteurella multocida]
VGRLKEVKILSAKSAVLARINKAMNGNFGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T123325 NZ_CP038874:2024948-2025232 [Pasteurella multocida]
GTGGGTCGGTTAAAGGAGGTAAAAATTTTATCCGCCAAATCTGCTGTTCTTGCTCGTATTAACAAAGCAATGAATGGTAA
TTTTGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10947.88 Da        Isoelectric Point: 8.9149

>AT123325 WP_061406133.1 NZ_CP038874:2025229-2025522 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALSDVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKIMHSLGIKLVPTHI

Download         Length: 294 bp

>AT123325 NZ_CP038874:2025229-2025522 [Pasteurella multocida]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAAGTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTATGCATTCCTTAGGTATTAAACTTGTCCCAACGCACATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References