Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 570720..571294 Replicon chromosome
Accession NZ_CP038873
Organism Pasteurella multocida strain FCf45

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E5135_RS02540 Protein ID WP_061406134.1
Coordinates 571010..571294 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag E5135_RS02535 Protein ID WP_061406133.1
Coordinates 570720..571013 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5135_RS02515 565879..566970 - 1092 WP_005751571.1 L-ascorbate 6-phosphate lactonase -
E5135_RS02520 567320..569110 + 1791 WP_061406132.1 PTS ascorbate-specific subunit IIBC -
E5135_RS02525 569155..569622 + 468 WP_064661066.1 PTS sugar transporter subunit IIA -
E5135_RS02530 569640..570317 + 678 WP_005726756.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
E5135_RS02535 570720..571013 - 294 WP_061406133.1 putative addiction module antidote protein Antitoxin
E5135_RS02540 571010..571294 - 285 WP_061406134.1 hypothetical protein Toxin
E5135_RS02550 572573..572932 - 360 WP_095261631.1 DUF3418 domain-containing protein -
E5135_RS02555 573076..573627 + 552 WP_196766247.1 NERD domain-containing protein -
E5135_RS02560 573912..575501 + 1590 WP_081106270.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-87)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10667.40 Da        Isoelectric Point: 10.2297

>T123321 WP_061406134.1 NZ_CP038873:c571294-571010 [Pasteurella multocida]
VGRLKEVKILSAKSAVLARINKAMNGNFGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T123321 NZ_CP038873:c571294-571010 [Pasteurella multocida]
GTGGGTCGGTTAAAGGAGGTAAAAATTTTATCCGCCAAATCTGCTGTTCTTGCTCGTATTAACAAAGCAATGAATGGTAA
TTTTGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10947.88 Da        Isoelectric Point: 8.9149

>AT123321 WP_061406133.1 NZ_CP038873:c571013-570720 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALSDVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKIMHSLGIKLVPTHI

Download         Length: 294 bp

>AT123321 NZ_CP038873:c571013-570720 [Pasteurella multocida]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAAGTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTATGCATTCCTTAGGTATTAAACTTGTCCCAACGCACATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References