Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1153571..1154145 Replicon chromosome
Accession NZ_CP038872
Organism Pasteurella multocida strain FCf71

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E5134_RS05390 Protein ID WP_061406134.1
Coordinates 1153571..1153855 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag E5134_RS05395 Protein ID WP_135938169.1
Coordinates 1153852..1154145 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5134_RS05370 1149364..1150953 - 1590 WP_081106270.1 AAA family ATPase -
E5134_RS05375 1151238..1151789 - 552 WP_196766247.1 NERD domain-containing protein -
E5134_RS05380 1151933..1152292 + 360 WP_095261631.1 DUF3418 domain-containing protein -
E5134_RS05390 1153571..1153855 + 285 WP_061406134.1 hypothetical protein Toxin
E5134_RS05395 1153852..1154145 + 294 WP_135938169.1 putative addiction module antidote protein Antitoxin
E5134_RS05400 1154548..1155225 - 678 WP_005726756.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
E5134_RS05405 1155243..1155710 - 468 WP_064661066.1 PTS sugar transporter subunit IIA -
E5134_RS05410 1155755..1157545 - 1791 WP_061406132.1 PTS ascorbate-specific subunit IIBC -
E5134_RS05415 1157895..1158986 + 1092 WP_005751571.1 L-ascorbate 6-phosphate lactonase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-87)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10667.40 Da        Isoelectric Point: 10.2297

>T123320 WP_061406134.1 NZ_CP038872:1153571-1153855 [Pasteurella multocida]
VGRLKEVKILSAKSAVLARINKAMNGNFGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T123320 NZ_CP038872:1153571-1153855 [Pasteurella multocida]
GTGGGTCGGTTAAAGGAGGTAAAAATTTTATCCGCCAAATCTGCTGTTCTTGCTCGTATTAACAAAGCAATGAATGGTAA
TTTTGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.83 Da        Isoelectric Point: 7.2766

>AT123320 WP_135938169.1 NZ_CP038872:1153852-1154145 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALSDVVRAKGMTELAAKTGLRRESLYKTLSYGSEPRFDT
IMKIMHSLGIKLVPTHI

Download         Length: 294 bp

>AT123320 NZ_CP038872:1153852-1154145 [Pasteurella multocida]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAAGTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCGAGCCACGTTTTGATACG
ATAATGAAAATTATGCATTCCTTAGGTATTAAACTTGTCCCAACGCACATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References