123312

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2322413..2323011 Replicon chromosome
Accession NZ_CP038860
Organism Geobacillus kaustophilus NBRC 102445

Toxin (Protein)


Gene name mazF Uniprot ID G8N5V4
Locus tag E5Z46_RS12085 Protein ID WP_011231143.1
Coordinates 2322682..2323011 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G8N5V3
Locus tag E5Z46_RS12080 Protein ID WP_011231142.1
Coordinates 2322413..2322682 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5Z46_RS12040 2318034..2319014 + 981 WP_011231139.1 ABC transporter permease -
E5Z46_RS12045 2319083..2319550 - 468 WP_021321939.1 hypothetical protein -
E5Z46_RS12050 2319564..2320404 - 841 Protein_2253 hypothetical protein -
E5Z46_RS12055 2320531..2321586 + 1056 WP_011231141.1 transposase -
E5Z46_RS12080 2322413..2322682 + 270 WP_011231142.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E5Z46_RS12085 2322682..2323011 + 330 WP_011231143.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E5Z46_RS12095 2323464..2324297 + 834 WP_011231146.1 pirin family protein -
E5Z46_RS12100 2324393..2325142 + 750 WP_033012810.1 oxygen-insensitive NADPH nitroreductase -
E5Z46_RS12105 2325332..2326075 + 744 WP_011231148.1 NAD-dependent protein deacylase -
E5Z46_RS12110 2326255..2327433 + 1179 WP_011231149.1 acyl-CoA dehydrogenase family protein -
E5Z46_RS12115 2327470..2327868 + 399 Protein_2261 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

Antitoxin PemI-like

(12-87)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12071.86 Da        Isoelectric Point: 7.1331

>T123312 WP_011231143.1 NZ_CP038860:2322682-2323011 [Geobacillus kaustophilus NBRC 102445]
MQAPDRGDLVYVNFNPQAGHEQAGKRPGIVLSPKRFNQLTGFAVLCPITRQQKGYPFEVELPSGLAVEGVILTDQVKSLD
WRARQLQIVGRAPNEVVSDCLDLIHTFLS

Download         Length: 330 bp

>T123312 NZ_CP038860:2322682-2323011 [Geobacillus kaustophilus NBRC 102445]
ATGCAAGCGCCGGATCGCGGGGATCTTGTTTACGTCAATTTCAATCCACAAGCAGGGCATGAGCAGGCAGGAAAAAGGCC
CGGCATCGTTCTATCACCAAAGCGGTTCAATCAATTGACAGGGTTTGCGGTGCTTTGCCCGATCACCCGGCAACAAAAAG
GATATCCATTTGAAGTGGAATTGCCATCAGGCTTGGCCGTTGAAGGCGTGATTTTAACCGATCAGGTCAAAAGTTTAGAT
TGGCGCGCCCGACAGCTTCAAATAGTAGGACGGGCGCCCAATGAAGTTGTTTCGGATTGCTTGGATCTGATTCATACTTT
TCTTTCGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9992.67 Da        Isoelectric Point: 7.2050

>AT123312 WP_011231142.1 NZ_CP038860:2322413-2322682 [Geobacillus kaustophilus NBRC 102445]
MELNKQKGVSIMTITVQKWGNSLAVRIPSVIAERLALHQGSEVEMIVENQAIKLIPKKKKPTLEELLAKITPENRHAEID
FGTEGNELF

Download         Length: 270 bp

>AT123312 NZ_CP038860:2322413-2322682 [Geobacillus kaustophilus NBRC 102445]
ATGGAATTAAACAAACAGAAAGGAGTGTCAATCATGACAATAACCGTTCAAAAATGGGGAAACAGCCTTGCGGTTCGCAT
CCCAAGCGTGATTGCTGAACGTTTAGCGCTTCATCAAGGATCAGAAGTGGAGATGATCGTTGAGAACCAAGCGATCAAGT
TGATCCCGAAAAAGAAAAAGCCGACATTGGAGGAACTTTTGGCTAAAATCACGCCGGAAAATCGCCATGCTGAAATTGAT
TTTGGAACAGAAGGGAATGAATTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9EUB7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9HWH2

References