Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2882755..2883590 Replicon chromosome
Accession NZ_CP038859
Organism Escherichia coli strain 357900

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2S4A272
Locus tag A7A13_RS13890 Protein ID WP_001094443.1
Coordinates 2882755..2883132 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag A7A13_RS13895 Protein ID WP_001285607.1
Coordinates 2883222..2883590 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A13_RS13845 2877799..2877981 - 183 WP_000500669.1 hypothetical protein -
A7A13_RS13850 2878046..2878529 + 484 Protein_2712 DUF45 domain-containing protein -
A7A13_RS13855 2878575..2880056 - 1482 WP_001293292.1 N-6 DNA methylase -
A7A13_RS13860 2880049..2880651 - 603 WP_000276816.1 restriction endonuclease subunit S -
A7A13_RS13865 2880668..2880853 - 186 WP_001003201.1 hypothetical protein -
A7A13_RS13870 2881129..2881356 - 228 Protein_2716 DUF4102 domain-containing protein -
A7A13_RS13875 2881822..2881968 - 147 WP_001290178.1 hypothetical protein -
A7A13_RS13880 2882053..2882250 - 198 WP_001327226.1 DUF957 domain-containing protein -
A7A13_RS13885 2882270..2882758 - 489 WP_000761685.1 hypothetical protein -
A7A13_RS13890 2882755..2883132 - 378 WP_001094443.1 TA system toxin CbtA family protein Toxin
A7A13_RS13895 2883222..2883590 - 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A7A13_RS13900 2883670..2883891 - 222 WP_000692350.1 DUF987 domain-containing protein -
A7A13_RS13905 2883978..2884454 - 477 WP_001186165.1 RadC family protein -
A7A13_RS13910 2884469..2884954 - 486 WP_000206664.1 antirestriction protein -
A7A13_RS13915 2885046..2885864 - 819 WP_001175163.1 DUF945 domain-containing protein -
A7A13_RS13920 2885954..2886187 - 234 WP_001278287.1 DUF905 family protein -
A7A13_RS13925 2886193..2886870 - 678 WP_001097301.1 hypothetical protein -
A7A13_RS13930 2887018..2887698 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.97 Da        Isoelectric Point: 7.3523

>T123301 WP_001094443.1 NZ_CP038859:c2883132-2882755 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T123301 NZ_CP038859:c2883132-2882755 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT123301 WP_001285607.1 NZ_CP038859:c2883590-2883222 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT123301 NZ_CP038859:c2883590-2883222 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4A272

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References