Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4518627..4519212 Replicon chromosome
Accession NZ_CP038856
Organism Citrobacter freundii strain Upstream_1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E5284_RS21600 Protein ID WP_135912739.1
Coordinates 4518627..4518941 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag E5284_RS21605 Protein ID WP_115259723.1
Coordinates 4518934..4519212 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5284_RS21575 4514741..4516321 + 1581 WP_135912736.1 RNA repair transcriptional activator RtcR -
E5284_RS21580 4516426..4516698 + 273 WP_096758747.1 DUF3811 domain-containing protein -
E5284_RS21585 4516695..4517570 - 876 WP_096758748.1 23S rRNA pseudouridine(2604) synthase RluF -
E5284_RS21590 4517821..4518138 - 318 WP_135912737.1 CcdB family protein -
E5284_RS21595 4518138..4518431 - 294 WP_135912738.1 type II toxin-antitoxin system CcdA family antitoxin -
E5284_RS21600 4518627..4518941 + 315 WP_135912739.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5284_RS21605 4518934..4519212 + 279 WP_115259723.1 putative addiction module antidote protein Antitoxin
E5284_RS21610 4519324..4520013 + 690 WP_115259724.1 dipeptidase PepE -
E5284_RS21615 4520142..4521773 - 1632 WP_096758756.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11969.88 Da        Isoelectric Point: 9.5570

>T123254 WP_135912739.1 NZ_CP038856:4518627-4518941 [Citrobacter freundii]
MEILQTMVFQRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGISEMRISYGPGYRIYFKQQGCHIIILLCGGDKSS
QANDITMAKMLARSLDYQEIRHHE

Download         Length: 315 bp

>T123254 NZ_CP038856:4518627-4518941 [Citrobacter freundii]
ATGGAAATTCTTCAGACAATGGTTTTCCAGCGTTGGGAGCAAAACCTACGGGACAGGAGAGCTAAAACGCTCATTGCTAC
ACGCCTTTTTCGTTTGGCTAATGGTTTAGCTGGTGATGTCAAACCTGTTGGAGAAGGCATCAGCGAAATGCGCATTTCCT
ACGGTCCTGGTTACAGGATTTACTTTAAACAGCAAGGCTGCCACATCATCATTTTGTTATGTGGGGGCGATAAAAGCTCA
CAAGCCAACGATATCACTATGGCAAAAATGCTCGCCCGTTCACTGGATTATCAAGAGATCCGCCACCATGAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9863.44 Da        Isoelectric Point: 6.3200

>AT123254 WP_115259723.1 NZ_CP038856:4518934-4519212 [Citrobacter freundii]
MNKLTRYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIELTLKK

Download         Length: 279 bp

>AT123254 NZ_CP038856:4518934-4519212 [Citrobacter freundii]
ATGAATAAACTTACTCGGTACGATCCCGCAACTGCGCTGGTTGATGATGAAGAAATTGCCGTATTTATGGCGGATGCCCT
CGAAACAGGCGATGCAGCGTACATTGCAAAAGCCCTGGGCGTGGTGGCTCGCGCTAAGGGAATGGCGAACATCGCGGCAG
AAACGGGATTATCCCGCGAACAACTTTATCGCTCTTTTAGTGAGAAAGGTAACCCAACGCTGAAAACTACGCTTGCAGTG
ATGAAGGCGCTCGGTATTGAATTGACACTTAAAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References