Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4432741..4433276 Replicon chromosome
Accession NZ_CP038856
Organism Citrobacter freundii strain Upstream_1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E5284_RS21200 Protein ID WP_135912716.1
Coordinates 4432989..4433276 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E5284_RS21195 Protein ID WP_135912715.1
Coordinates 4432741..4432992 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5284_RS21165 4427753..4428601 + 849 WP_135912711.1 alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ -
E5284_RS21170 4428598..4429356 + 759 WP_135912712.1 phosphonate C-P lyase system protein PhnK -
E5284_RS21175 4429465..4430145 + 681 WP_117343579.1 phosphonate C-P lyase system protein PhnL -
E5284_RS21180 4430142..4431278 + 1137 WP_096758663.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
E5284_RS21185 4431281..4431826 + 546 WP_135912713.1 ribose 1,5-bisphosphokinase -
E5284_RS21190 4431899..4432657 + 759 WP_135912714.1 phosphonate metabolism protein PhnP -
E5284_RS21195 4432741..4432992 + 252 WP_135912715.1 antitoxin Antitoxin
E5284_RS21200 4432989..4433276 + 288 WP_135912716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5284_RS21205 4433273..4433602 - 330 WP_096758667.1 hypothetical protein -
E5284_RS21210 4433671..4435935 - 2265 WP_135912717.1 hybrid sensor histidine kinase/response regulator -
E5284_RS21220 4436050..4437573 + 1524 WP_096758669.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11173.96 Da        Isoelectric Point: 10.1922

>T123253 WP_135912716.1 NZ_CP038856:4432989-4433276 [Citrobacter freundii]
MSYTVTFREDALKEWQKLDKTIQQQFARELKKCGENPHVPSAKLRGIKDCYKIQLRTSRFRLVYQVIDDTLVIAVVAVGK
RERSEVYNLASERLR

Download         Length: 288 bp

>T123253 NZ_CP038856:4432989-4433276 [Citrobacter freundii]
ATGAGTTATACGGTAACATTCAGGGAAGATGCGCTGAAAGAATGGCAAAAATTGGATAAAACCATTCAGCAGCAGTTTGC
CAGAGAACTCAAGAAATGCGGTGAAAATCCGCATGTCCCCTCCGCGAAGCTCAGGGGAATAAAAGATTGCTATAAAATCC
AACTACGCACTTCAAGGTTCCGTCTTGTTTATCAAGTTATTGACGACACCCTGGTCATCGCTGTCGTTGCCGTCGGTAAA
CGCGAGCGTAGTGAAGTTTATAATCTTGCCAGCGAAAGGCTACGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9214.55 Da        Isoelectric Point: 4.4262

>AT123253 WP_135912715.1 NZ_CP038856:4432741-4432992 [Citrobacter freundii]
MPHIILSDTTASVSELKKNPMATVSAGNGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Download         Length: 252 bp

>AT123253 NZ_CP038856:4432741-4432992 [Citrobacter freundii]
ATGCCACATATCATTTTAAGCGACACCACCGCCAGCGTGAGTGAGCTAAAAAAGAACCCGATGGCGACTGTTAGCGCAGG
GAATGGGTTTCCGGTCGCAATCCTGAACCGTAACCAGCCCGCCTTTTATTGTGTTCCCGCTGAGCTTTACGAAAAAATGC
TTGATGCGCTGGACGATCAGCAACTGGTTAAATTAGTCCATGAACGGAGCCAACAGCCACTGGTGGATGTTGATCTGGAC
AGCTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References