Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 821399..822053 Replicon chromosome
Accession NZ_CP038856
Organism Citrobacter freundii strain Upstream_1

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag E5284_RS04070 Protein ID WP_096755799.1
Coordinates 821646..822053 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag E5284_RS04065 Protein ID WP_096755798.1
Coordinates 821399..821665 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5284_RS04035 816613..818046 - 1434 WP_115257538.1 6-phospho-beta-glucosidase BglA -
E5284_RS04040 818167..818895 - 729 WP_115259901.1 MurR/RpiR family transcriptional regulator -
E5284_RS04045 818948..819259 + 312 WP_096755795.1 N(4)-acetylcytidine aminohydrolase -
E5284_RS04050 819423..820082 + 660 WP_096755796.1 hemolysin III family protein -
E5284_RS04055 820162..821142 - 981 WP_115257540.1 tRNA-modifying protein YgfZ -
E5284_RS04065 821399..821665 + 267 WP_096755798.1 FAD assembly factor SdhE Antitoxin
E5284_RS04070 821646..822053 + 408 WP_096755799.1 protein YgfX Toxin
E5284_RS04075 822099..822620 - 522 WP_096755800.1 flavodoxin FldB -
E5284_RS04080 822733..823629 + 897 WP_096755801.1 site-specific tyrosine recombinase XerD -
E5284_RS04085 823653..824366 + 714 WP_096755802.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E5284_RS04090 824372..826105 + 1734 WP_096755803.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15935.93 Da        Isoelectric Point: 11.2851

>T123241 WP_096755799.1 NZ_CP038856:821646-822053 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQPSMQK

Download         Length: 408 bp

>T123241 NZ_CP038856:821646-822053 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAGTGGATTTCGTTGCTCATTCATGGGCTAGTGGCGGT
GCTTATTTTATTGATGCCATGGCCACTGAGTTACACCCCTTTATGGTTGATTTTGCTCTCTCTGGTGGTGTTCGATTGCG
TGCGCAGTCAGCGCCGTATCAACGCTTGTCAGGGAGAGATTAGACTATTGATGGATGGCCGCCTGCGTTGGCAAGGGCAA
GAGTGGTCGATTGTTAGCGCACCCTGGATGATAAAAACGGGCATGATGTTGCGTTTGCGGTCAAGTACAGGAAAGCGTCA
GCATCTGTGGCTGGCGGCGGACAGCATGGATGATGCTGAATGGCGGGATTTGCGTCGGTTGATATTACAACCGTCAATGC
AGAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.10 Da        Isoelectric Point: 5.6311

>AT123241 WP_096755798.1 NZ_CP038856:821399-821665 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT123241 NZ_CP038856:821399-821665 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTGGACATTTCGATCATGCCGTT
TTTCGAACATGAGTATGACAACTTAAGTGATGACGAAAAGCGCATTTTTATCCGTTTGCTGGAATGTGATGACCCCGATT
TATTTAACTGGTTGATGAATCACGGGAAGCCGGCTGATGCACAGCTGGAGCAAATGGTACGGCTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References