Detailed information of TA system TA123239

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 102969..103504
• Replicon: plasmid pVag2
• Accession: NZ_CP038855
• Organism: Pantoea vagans strain LMG 24199

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EGO56_RS21930
• Protein ID: WP_135911126.1
• Coordinates: 102969..103256 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EGO56_RS21935
• Protein ID: WP_135911127.1
• Coordinates: 103253..103504 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGO56_RS21920	99061..101118	-	2058	WP_135911124.1	hydantoinase/oxoprolinase family protein	-
EGO56_RS21925	101330..102805	+	1476	WP_135911125.1	Sapep family Mn(2+)-dependent dipeptidase	-
EGO56_RS21930	102969..103256	-	288	WP_135911126.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGO56_RS21935	103253..103504	-	252	WP_135911127.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EGO56_RS21940	103770..104903	-	1134	WP_135911128.1	glutathione-independent formaldehyde dehydrogenase	-
EGO56_RS21945	105263..106210	-	948	WP_135911129.1	sulfonate ABC transporter substrate-binding protein	-
EGO56_RS21950	106306..108195	-	1890	WP_135911130.1	sigma-54-dependent Fis family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..180464	180464

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11175.10 Da
• Isoelectric Point: 10.3527

>T123239 WP_135911126.1 NZ_CP038855:c103256-102969 [Pantoea vagans]
VSYTVKFREEAFKEWQKLDKSLQQQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRSSGFRLVYQVIDDHLIIAVVAVGK
RERSDVYNLASERMR

Nucleotide

• Length: 288 bp

>T123239 NZ_CP038855:c103256-102969 [Pantoea vagans]
GTGAGTTATACGGTCAAATTCAGAGAAGAGGCTTTTAAAGAATGGCAGAAGCTGGACAAATCTCTTCAGCAGCAGTTTGC
TAAAAAGCTGAAGAAATGTTGTGAGAATCCCCATATCCCCTCGGCAAAACTACGTGGGATTAAAGACTGCTACAAAATCA
AACTGCGGTCATCCGGTTTTCGGCTGGTTTATCAGGTGATCGACGATCACCTGATCATTGCCGTAGTGGCTGTCGGTAAA
CGTGAGCGCAGCGATGTTTACAACCTCGCCAGTGAGAGAATGCGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9207.47 Da
• Isoelectric Point: 3.9504

>AT123239 WP_135911127.1 NZ_CP038855:c103504-103253 [Pantoea vagans]
MPHIILSDTSASVSELKKNPMATVNAGDGYPVAILNRNQPAFYCVPAELYEQMLDALDDQELTKLVYERSNQPLLDVDLD
ALL

Nucleotide

• Length: 252 bp

>AT123239 NZ_CP038855:c103504-103253 [Pantoea vagans]
ATGCCACACATCATTTTAAGCGATACCAGTGCCAGCGTCAGTGAACTGAAAAAAAACCCGATGGCCACTGTCAATGCCGG
GGACGGTTATCCCGTTGCGATTCTCAACCGCAACCAGCCTGCATTCTATTGCGTCCCGGCTGAGTTGTATGAACAGATGC
TTGATGCCCTTGACGATCAGGAACTGACTAAGCTGGTCTACGAACGCAGCAATCAGCCTCTGCTTGATGTCGATCTGGAT
GCGCTTTTGTGA