123230

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2069120..2070681 Replicon chromosome
Accession NZ_CP038853
Organism Pantoea vagans strain LMG 24199

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EGO56_RS09620 Protein ID WP_135908766.1
Coordinates 2069368..2070681 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EGO56_RS09615 Protein ID WP_135908764.1
Coordinates 2069120..2069368 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGO56_RS09595 2064370..2066595 + 2226 WP_135908756.1 iron ABC transporter permease -
EGO56_RS09600 2066592..2067653 + 1062 WP_135908758.1 ABC transporter ATP-binding protein -
EGO56_RS09605 2067677..2068468 + 792 WP_135908760.1 inositol monophosphatase family protein -
EGO56_RS09610 2068502..2068939 - 438 WP_135908762.1 GNAT family N-acetyltransferase -
EGO56_RS09615 2069120..2069368 + 249 WP_135908764.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EGO56_RS09620 2069368..2070681 + 1314 WP_135908766.1 type II toxin-antitoxin system HipA family toxin Toxin
EGO56_RS09625 2070786..2070992 + 207 WP_013357880.1 type II toxin-antitoxin system MqsA family antitoxin -
EGO56_RS09630 2071220..2072602 + 1383 WP_135908768.1 M24 family metallopeptidase -
EGO56_RS09635 2072683..2073327 + 645 WP_135908770.1 LysE family translocator -
EGO56_RS09640 2073477..2075522 + 2046 WP_135908772.1 FUSC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49258.69 Da        Isoelectric Point: 8.4318

>T123230 WP_135908766.1 NZ_CP038853:2069368-2070681 [Pantoea vagans]
MQRLNAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSLPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDEARLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTEEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGKMRALAVERFDRRW
SRDRTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLTGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNRRALKLAMGLRATKGKKTEIDKIFPRHFIATAKQVNFDRDSLQQIFDFFVREFP
KAVVSVREALPADFPQHIADAIFSHSLIMLERLRHND

Download         Length: 1314 bp

>T123230 NZ_CP038853:2069368-2070681 [Pantoea vagans]
ATGCAAAGGCTGAATGCGTGGATGAACGGTGAGCGGGTAGGCGTGCTTACCCGGCAGCGGAATGGCGCTCATGAGTTTCA
GTATGACACCGGCTGGCTGAGTAACCCGCTCTCCAGGCCGCTGTCACTTTCTCTGCCGTTGCAGGTTAAGGCGATTACCT
CACACGCCGTAATTAACTTCTTCGATAACCTGCTGCCGGATAGCCCGTTGATTCGTGACAGGATCGTGGCGCGTTACCAG
ATTAAATCCCGTCAGCCGTTTGACCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGGGCGACCATGCTGTTGCCGCCCGA
TATGCCGCTGCCCGCACTGCAGGCTCGCTATGAGGTGCTGGATGAAGCCCGGCTCGAGAGCGTGCTGTCAGCCTATCAGT
CCGATATCCCGCTGGGGATGCTGCGTGAAGAGACCGACTTCCGCATTTCGGTGGCGGGCGCACAGGAGAAAACGGCGCTG
CTGCTGACCGAAGAGGGCTGGAGCATTCCTGCCGGCGCCACGCCCACCTCGCACATTATCAAGCTGCCAATCGGTGAGAT
TAAACAACCAGCCGCGACGCTGGATATGCGTGAAAGCGTAGAGAACGAATATCTTTGTCTGGCGCTGGCCCGCGCACTGG
GTATTGATGTGCCGCAGGCGACGATTATCCGGGCCGGTAAGATGCGCGCCCTGGCCGTTGAGCGCTTTGACCGCCGCTGG
TCGCGCGACCGGACCCGGCTGATTCGTCTGCCACAGGAGGATTTCTGTCAGGCGCTGGGGCTGCCATCCTCGACTAAATA
TGAGTCGGACGGCGGGCCGGGCATCGCAGAAATAATGCAGATACTGATGGGATCGAGCAATGCCATCGAGGATCGCTATC
GCTTTATGATGTTCCAGGTGTTTCAGTGGCTGACGGGCGCAACCGATGGTCACGCTAAAAACTTCTCGCTGTTTATCGAG
CGCGGCGGCAGTTATCGACTGACACCCTTTTATGATGTGATCTCCGCTTATCCGGTGCTGGGTGGTACCGGCCTGAACAG
GCGTGCACTCAAACTGGCGATGGGGCTGCGTGCCACTAAGGGAAAGAAGACAGAAATCGACAAAATCTTTCCGCGCCATT
TTATCGCCACGGCGAAGCAGGTGAATTTTGATCGTGACAGCCTGCAGCAGATCTTTGACTTCTTCGTCCGTGAGTTTCCA
AAGGCGGTAGTCTCAGTGCGCGAGGCCTTACCGGCCGATTTCCCGCAGCACATCGCGGATGCAATCTTCAGCCATTCACT
GATTATGCTGGAACGGTTACGGCATAACGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9296.52 Da        Isoelectric Point: 5.0637

>AT123230 WP_135908764.1 NZ_CP038853:2069120-2069368 [Pantoea vagans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENSPDSTSLATLFKLLQALEVSLDVVEKEEASASQLHDED
EW

Download         Length: 249 bp

>AT123230 NZ_CP038853:2069120-2069368 [Pantoea vagans]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTTATCCGCCAGCGCAATGGCTGGACCCAGAGTGAACTGGC
AAAAAAGGTGGGCCTGAAACAGGCCACCATCTCTCACTTTGAAAATTCGCCTGACAGTACTTCGCTGGCCACGCTGTTTA
AGCTTTTACAGGCGCTGGAAGTGAGTCTGGACGTAGTGGAAAAAGAGGAGGCCAGTGCGTCTCAGTTGCATGATGAGGAT
GAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References