Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2107335..2107849 Replicon chromosome
Accession NZ_CP038819
Organism Staphylococcus aureus strain O82

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag SaO82_RS10670 Protein ID WP_000603099.1
Coordinates 2107335..2107544 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag SaO82_RS10675 Protein ID WP_000138933.1
Coordinates 2107556..2107849 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO82_RS10650 2102843..2104201 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SaO82_RS10655 2104216..2105286 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
SaO82_RS10660 2105604..2106806 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SaO82_RS10665 2107070..2107207 - 138 WP_000828354.1 hypothetical protein -
SaO82_RS10670 2107335..2107544 - 210 WP_000603099.1 heavy-metal-associated domain-containing protein Toxin
SaO82_RS10675 2107556..2107849 - 294 WP_000138933.1 copper-sensing transcriptional repressor CsoR Antitoxin
SaO82_RS10680 2108015..2109499 + 1485 WP_000571551.1 cardiolipin synthase -
SaO82_RS10685 2109527..2110189 + 663 WP_001187618.1 HD domain-containing protein -
SaO82_RS10695 2110746..2111618 - 873 WP_000725802.1 membrane protein insertase YidC -
SaO82_RS10700 2111704..2112345 - 642 WP_000483158.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7819.79 Da        Isoelectric Point: 3.9389

>T123222 WP_000603099.1 NZ_CP038819:c2107544-2107335 [Staphylococcus aureus]
MILQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T123222 NZ_CP038819:c2107544-2107335 [Staphylococcus aureus]
ATGATACTTCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.81 Da        Isoelectric Point: 6.7122

>AT123222 WP_000138933.1 NZ_CP038819:c2107849-2107556 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNKGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT123222 NZ_CP038819:c2107849-2107556 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATAAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References