Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 878978..879455 Replicon chromosome
Accession NZ_CP038819
Organism Staphylococcus aureus strain O82

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SaO82_RS04365 Protein ID WP_000052076.1
Coordinates 878978..879166 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SaO82_RS04370 Protein ID WP_001059690.1
Coordinates 879195..879455 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO82_RS04335 875018..875488 + 471 WP_115210962.1 hypothetical protein -
SaO82_RS04340 875829..876515 + 687 WP_000141556.1 thermonuclease family protein -
SaO82_RS04345 876872..877072 + 201 WP_001059082.1 cold-shock protein -
SaO82_RS04350 877569..877787 - 219 WP_000005883.1 hypothetical protein -
SaO82_RS04355 877849..878133 - 285 WP_001004401.1 hypothetical protein -
SaO82_RS04360 878221..878790 - 570 WP_001106647.1 hypothetical protein -
SaO82_RS04365 878978..879166 - 189 WP_000052076.1 hypothetical protein Toxin
SaO82_RS04370 879195..879455 - 261 WP_001059690.1 hypothetical protein Antitoxin
SaO82_RS04375 879796..879999 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SaO82_RS04380 879996..880232 - 237 WP_000368687.1 hypothetical protein -
SaO82_RS04385 880457..881038 + 582 WP_001140691.1 phosphoglycerate mutase family protein -
SaO82_RS04390 881111..881728 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
SaO82_RS04395 881885..882379 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SaO82_RS04400 882778..883200 - 423 WP_000974457.1 organic hydroperoxide resistance protein -
SaO82_RS04405 883348..884064 + 717 WP_000150028.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T123219 WP_000052076.1 NZ_CP038819:c879166-878978 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T123219 NZ_CP038819:c879166-878978 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT123219 WP_001059690.1 NZ_CP038819:c879455-879195 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT123219 NZ_CP038819:c879455-879195 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References