Detailed information of TA system TA123211

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1438531..1439162
• Replicon: chromosome
• Accession: NZ_CP038817
• Organism: Haemophilus parahaemolyticus strain NEB129

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E5Q53_RS06935
• Protein ID: WP_005706920.1
• Coordinates: 1438531..1438929 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: I2NCV5
• Locus tag: E5Q53_RS06940
• Protein ID: WP_005706948.1
• Coordinates: 1438929..1439162 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5Q53_RS06920	1434902..1435615	-	714	WP_143413720.1	hypothetical protein	-
E5Q53_RS06925	1435852..1436778	+	927	WP_005706977.1	zinc ABC transporter substrate-binding protein ZnuA	-
E5Q53_RS06930	1436976..1438511	-	1536	WP_005706963.1	L-2,4-diaminobutyrate decarboxylase	-
E5Q53_RS06935	1438531..1438929	-	399	WP_005706920.1	tRNA(fMet)-specific endonuclease VapC	Toxin
E5Q53_RS06940	1438929..1439162	-	234	WP_005706948.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E5Q53_RS06945	1439309..1440673	-	1365	WP_005706918.1	diaminobutyrate--2-oxoglutarate transaminase	-
E5Q53_RS06950	1441025..1441195	-	171	WP_005706939.1	50S ribosomal protein L33	-
E5Q53_RS06955	1441207..1441443	-	237	WP_005599762.1	50S ribosomal protein L28	-
E5Q53_RS06960	1441691..1442269	-	579	Protein_1321	molecular chaperone TorD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-56)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15057.37 Da
• Isoelectric Point: 8.0500

>T123211 WP_005706920.1 NZ_CP038817:c1438929-1438531 [Haemophilus parahaemolyticus]
VLKYMLDTNIVIYVIKRRPLEVLSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNLAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLKEFERVPALRTENWV

Nucleotide

• Length: 399 bp

>T123211 NZ_CP038817:c1438929-1438531 [Haemophilus parahaemolyticus]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGACCATTGGAAGTTCTTTCTCGCTTTAA
TCAAAATGCAGGGAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACCTTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAAAGAATTTGAGCGAGTTCCCGCATTGCGTACAGAAAATTGGGTGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8907.06 Da
• Isoelectric Point: 4.4013

>AT123211 WP_005706948.1 NZ_CP038817:c1439162-1438929 [Haemophilus parahaemolyticus]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVLGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Nucleotide

• Length: 234 bp

>AT123211 NZ_CP038817:c1439162-1438929 [Haemophilus parahaemolyticus]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCCGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATTAGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Structures

Antitoxin

• AlphaFold DB: I2NCV5