Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelB(antitoxin) |
| Location | 1986054..1986678 | Replicon | chromosome |
| Accession | NZ_CP038809 | ||
| Organism | Streptococcus agalactiae strain SS1168 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A076ZDW1 |
| Locus tag | AGP54_RS09995 | Protein ID | WP_000253103.1 |
| Coordinates | 1986054..1986401 (-) | Length | 116 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A076YVN5 |
| Locus tag | AGP54_RS10000 | Protein ID | WP_000543070.1 |
| Coordinates | 1986391..1986678 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AGP54_RS09975 (AGP54_10350) | 1981769..1982125 | - | 357 | WP_000105934.1 | DUF1304 domain-containing protein | - |
| AGP54_RS09980 (AGP54_10355) | 1982192..1984510 | - | 2319 | WP_000883414.1 | YhgE/Pip domain-containing protein | - |
| AGP54_RS09985 (AGP54_10360) | 1984649..1985188 | + | 540 | WP_000245858.1 | TetR/AcrR family transcriptional regulator C-terminal domain-containing protein | - |
| AGP54_RS09990 (AGP54_10365) | 1985274..1985570 | - | 297 | WP_001052249.1 | DUF4298 domain-containing protein | - |
| AGP54_RS09995 (AGP54_10370) | 1986054..1986401 | - | 348 | WP_000253103.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AGP54_RS10000 (AGP54_10375) | 1986391..1986678 | - | 288 | WP_000543070.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| AGP54_RS10005 (AGP54_10380) | 1986747..1987124 | - | 378 | WP_220298503.1 | ArpU family phage packaging/lysis transcriptional regulator | - |
| AGP54_RS10010 (AGP54_10385) | 1987099..1987251 | - | 153 | Protein_1909 | DUF1492 domain-containing protein | - |
| AGP54_RS10015 (AGP54_10390) | 1987258..1987746 | - | 489 | WP_000891151.1 | hypothetical protein | - |
| AGP54_RS10020 (AGP54_10395) | 1987819..1988376 | - | 558 | WP_001258765.1 | hypothetical protein | - |
| AGP54_RS10025 (AGP54_10400) | 1988534..1988707 | - | 174 | WP_000694573.1 | hypothetical protein | - |
| AGP54_RS10030 (AGP54_10405) | 1988704..1988961 | - | 258 | WP_001069293.1 | hypothetical protein | - |
| AGP54_RS10035 (AGP54_10410) | 1989254..1990648 | - | 1395 | WP_000656430.1 | VapE family protein | - |
| AGP54_RS10040 (AGP54_10415) | 1990660..1991517 | - | 858 | WP_001029296.1 | primase alpha helix C-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13333.09 Da Isoelectric Point: 5.1643
>T123200 WP_000253103.1 NZ_CP038809:c1986401-1986054 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK
Download Length: 348 bp
>T123200 NZ_CP038809:c1986401-1986054 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10605.98 Da Isoelectric Point: 4.8430
>AT123200 WP_000543070.1 NZ_CP038809:c1986678-1986391 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI
Download Length: 288 bp
>AT123200 NZ_CP038809:c1986678-1986391 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A076ZDW1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A076YVN5 |