Detailed information of TA system TA123199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 239029..239641
• Replicon: chromosome
• Accession: NZ_CP038809
• Organism: Streptococcus agalactiae strain SS1168

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: AGP54_RS01410
• Protein ID: WP_000384859.1
• Coordinates: 239029..239364 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: AGP54_RS01415
• Protein ID: WP_000259017.1
• Coordinates: 239354..239641 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AGP54_RS01385 (AGP54_01415)	234227..234868	+	642	Protein_217	hypothetical protein	-
AGP54_RS01390 (AGP54_01425)	235168..236043	+	876	WP_000421240.1	hypothetical protein	-
AGP54_RS01395 (AGP54_01430)	236079..236513	+	435	WP_001220479.1	hypothetical protein	-
AGP54_RS01400 (AGP54_01435)	236830..238086	+	1257	WP_000122836.1	MobV family relaxase	-
AGP54_RS01405 (AGP54_01440)	238254..238724	+	471	WP_000130119.1	hypothetical protein	-
AGP54_RS01410 (AGP54_01445)	239029..239364	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AGP54_RS01415 (AGP54_01450)	239354..239641	-	288	WP_000259017.1	hypothetical protein	Antitoxin
AGP54_RS01420 (AGP54_01455)	240044..241264	-	1221	WP_000156558.1	site-specific integrase	-
AGP54_RS01425 (AGP54_01460)	241325..241585	-	261	WP_001196072.1	helix-turn-helix domain-containing protein	-
AGP54_RS01430 (AGP54_01465)	241597..242343	-	747	WP_000966632.1	hypothetical protein	-
AGP54_RS01435 (AGP54_01470)	242529..243338	-	810	WP_228369132.1	FtsK/SpoIIIE domain-containing protein	-
AGP54_RS01440 (AGP54_01475)	243301..243834	-	534	WP_000680721.1	hypothetical protein	-
AGP54_RS01445 (AGP54_01480)	243834..244172	-	339	WP_001187920.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T123199 WP_000384859.1 NZ_CP038809:c239364-239029 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T123199 NZ_CP038809:c239364-239029 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT123199 WP_000259017.1 NZ_CP038809:c239641-239354 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT123199 NZ_CP038809:c239641-239354 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6