Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1587347..1588015 Replicon chromosome
Accession NZ_CP038808
Organism Streptococcus pneumoniae strain R6CIB17

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag E5Q10_RS08365 Protein ID WP_001132285.1
Coordinates 1587836..1588015 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag E5Q10_RS08360 Protein ID WP_000961810.1
Coordinates 1587347..1587799 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5Q10_RS08335 1583237..1583980 - 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
E5Q10_RS08340 1583982..1584932 - 951 WP_000451131.1 50S ribosomal protein L11 methyltransferase -
E5Q10_RS08345 1585070..1585498 - 429 WP_000418176.1 NUDIX hydrolase -
E5Q10_RS08350 1585464..1586567 - 1104 WP_000719717.1 M50 family metallopeptidase -
E5Q10_RS08355 1586586..1587056 - 471 WP_000257105.1 DUF3013 family protein -
E5Q10_RS08360 1587347..1587799 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E5Q10_RS08365 1587836..1588015 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
E5Q10_RS08370 1588152..1588331 - 180 WP_001809903.1 hypothetical protein -
E5Q10_RS08380 1588496..1588735 - 240 WP_000818079.1 hypothetical protein -
E5Q10_RS08390 1589005..1590276 + 1272 WP_001113205.1 replication-associated recombination protein A -
E5Q10_RS08400 1590823..1592142 - 1320 WP_000608887.1 glycoside hydrolase family 32 protein -
E5Q10_RS08405 1592152..1592997 - 846 WP_000819520.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T123198 WP_001132285.1 NZ_CP038808:c1588015-1587836 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T123198 NZ_CP038808:c1588015-1587836 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT123198 WP_000961810.1 NZ_CP038808:c1587799-1587347 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT123198 NZ_CP038808:c1587799-1587347 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATTAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References