Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2493094..2493612 Replicon chromosome
Accession NZ_CP038807
Organism Staphylococcus lugdunensis strain APC 3758

Toxin (Protein)


Gene name TsdT Uniprot ID A0A853V532
Locus tag E5Z44_RS11855 Protein ID WP_002492077.1
Coordinates 2493094..2493306 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag E5Z44_RS11860 Protein ID WP_002492098.1
Coordinates 2493319..2493612 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5Z44_RS11835 2488460..2489818 - 1359 WP_002492089.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E5Z44_RS11840 2489836..2490906 - 1071 WP_002461204.1 D-alanine--D-alanine ligase -
E5Z44_RS11845 2491262..2492452 + 1191 WP_002461205.1 rod shape-determining protein RodA -
E5Z44_RS11850 2492866..2493003 - 138 WP_002461206.1 hypothetical protein -
E5Z44_RS11855 2493094..2493306 - 213 WP_002492077.1 heavy-metal-associated domain-containing protein Toxin
E5Z44_RS11860 2493319..2493612 - 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
E5Z44_RS11865 2493778..2495262 + 1485 WP_002478972.1 cardiolipin synthase -
E5Z44_RS11870 2495384..2496025 + 642 WP_002492092.1 HD domain-containing protein -
E5Z44_RS11875 2496409..2497284 - 876 WP_002461212.1 membrane protein insertase YidC -
E5Z44_RS11880 2497374..2498012 - 639 WP_002492090.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8087.02 Da        Isoelectric Point: 3.9947

>T123194 WP_002492077.1 NZ_CP038807:c2493306-2493094 [Staphylococcus lugdunensis]
VEKRLIYITNVTNEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETSTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

>T123194 NZ_CP038807:c2493306-2493094 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAATGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTCGAAACATCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT123194 WP_002492098.1 NZ_CP038807:c2493612-2493319 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp

>AT123194 NZ_CP038807:c2493612-2493319 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAGATGCTAAAAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V532

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References