Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2481697..2482214 Replicon chromosome
Accession NZ_CP038807
Organism Staphylococcus lugdunensis strain APC 3758

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag E5Z44_RS11795 Protein ID WP_002461192.1
Coordinates 2481697..2482047 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag E5Z44_RS11800 Protein ID WP_002461193.1
Coordinates 2482044..2482214 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5Z44_RS11775 2478619..2479389 - 771 WP_002461188.1 RNA polymerase sigma factor SigB -
E5Z44_RS11780 2479364..2479843 - 480 WP_002492094.1 anti-sigma B factor RsbW -
E5Z44_RS11785 2479845..2480171 - 327 WP_002461190.1 anti-sigma factor antagonist -
E5Z44_RS11790 2480262..2481263 - 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
E5Z44_RS11795 2481697..2482047 - 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E5Z44_RS11800 2482044..2482214 - 171 WP_002461193.1 hypothetical protein Antitoxin
E5Z44_RS11805 2482301..2483449 - 1149 WP_002492086.1 alanine racemase -
E5Z44_RS11810 2483497..2483889 - 393 WP_002461196.1 holo-ACP synthase -
E5Z44_RS11815 2483901..2484413 - 513 WP_002461197.1 PH domain-containing protein -
E5Z44_RS11820 2484400..2485914 - 1515 WP_002492082.1 PH domain-containing protein -
E5Z44_RS11825 2485907..2486389 - 483 WP_002492078.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T123193 WP_002461192.1 NZ_CP038807:c2482047-2481697 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T123193 NZ_CP038807:c2482047-2481697 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
TATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGTTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT123193 WP_002461193.1 NZ_CP038807:c2482214-2482044 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT123193 NZ_CP038807:c2482214-2482044 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTTCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References