Detailed information of TA system TA123191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2327576..2328385
• Replicon: chromosome
• Accession: NZ_CP038807
• Organism: Staphylococcus lugdunensis strain APC 3758

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: E5Z44_RS12345
• Protein ID: WP_002458758.1
• Coordinates: 2327576..2327746 (-)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A853V5R2
• Locus tag: E5Z44_RS10905
• Protein ID: WP_002458757.1
• Coordinates: 2327786..2328385 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5Z44_RS10880	2322669..2323292	-	624	WP_002492614.1	response regulator transcription factor	-
E5Z44_RS10885	2323314..2324426	-	1113	WP_002492606.1	GAF domain-containing sensor histidine kinase	-
E5Z44_RS10890	2324594..2325430	+	837	WP_002477978.1	RluA family pseudouridine synthase	-
E5Z44_RS10895	2325495..2326880	-	1386	WP_002492636.1	class II fumarate hydratase	-
E5Z44_RS10900	2327008..2327403	-	396	WP_002458759.1	hypothetical protein	-
E5Z44_RS12345	2327576..2327746	-	171	WP_002458758.1	hypothetical protein	Toxin
E5Z44_RS10905	2327786..2328385	-	600	WP_002458757.1	glucosamine-6-phosphate isomerase	Antitoxin
E5Z44_RS10910	2328551..2329021	-	471	WP_002458756.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
E5Z44_RS10915	2329023..2330165	-	1143	WP_094449181.1	tRNA epoxyqueuosine(34) reductase QueG	-
E5Z44_RS10920	2330623..2331348	-	726	WP_002477975.1	amino acid ABC transporter ATP-binding protein	-
E5Z44_RS10925	2331341..2332798	-	1458	WP_002477974.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6565.10 Da
• Isoelectric Point: 4.6723

>T123191 WP_002458758.1 NZ_CP038807:c2327746-2327576 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Nucleotide

• Length: 171 bp

>T123191 NZ_CP038807:c2327746-2327576 [Staphylococcus lugdunensis]
ATGTCAAAAGAAAAAAAGAGTCGTTTAAATTATCATGAGGAAGAGAATGCGATGGTTGAAAATTTAGAAGACTTAAAAGA
GCTGGGCAAAGAAATGGAACACATCTCAGAGAAAAATGACGAAGAAAAAGTTAATCAATCGCATGATACATCAAAGTCTT
CAAATTCATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22619.51 Da
• Isoelectric Point: 4.9539

>AT123191 WP_002458757.1 NZ_CP038807:c2328385-2327786 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLILQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Nucleotide

• Length: 600 bp

>AT123191 NZ_CP038807:c2328385-2327786 [Staphylococcus lugdunensis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAAAGATCAAGTTGCAGAGTATTCAGCAGATATCATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCTGGATTTCATTTAAACAAAGAGGCATCACCAGTACTTGATATGCTTAAAAAGAATGTTG
ACCAACATGCGGTTGACTTCAGCCAAATTAACATTCTTGACTATGATCAAAATCAAGAATATTTCAAAGCGCTGGGGGTT
CCTGAGAGTCAAATTTATCCTATCTCATACGATCAAGATGCTGAAGCGTTTATCTCTGATAAAATCAAAACAAAAGATAA
TAAAGGGAAACTAATATTACAAGTAGCTTCAATTGATGATCAAGGAAACCTTAATATCAGTCTACGTCAAGGATTGTTAA
ATGCTAGAGAAATTATCTTAGTCATTACAGGACATAATAAAAAAGAAGTAGTAGAAAAACTGTATAATGAAAATGGAAAA
TCTAATTTTGAACCTGCTGATTTAAAAGCACATCGTATGGTAACGGTTATTTTAGACGAAGCGGCAGCTGAAGGTTTGCC
AGAAGATGTACGTCATTACTTTACTGATCGGTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A853V5R2