Detailed information of TA system TA123187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2505078..2505703
• Replicon: chromosome
• Accession: NZ_CP038804
• Organism: Treponema putidum strain OMZ 835

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E4N74_RS11605
• Protein ID: WP_255817850.1
• Coordinates: 2505078..2505473 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: S3LQE6
• Locus tag: E4N74_RS11610
• Protein ID: WP_002692300.1
• Coordinates: 2505473..2505703 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N74_RS11585 (E4N74_11880)	2500951..2501787	+	837	WP_255817842.1	FAD-dependent thymidylate synthase	-
E4N74_RS11590 (E4N74_11885)	2501806..2503530	+	1725	WP_255817844.1	TrkH family potassium uptake protein	-
E4N74_RS11595 (E4N74_11890)	2503542..2504234	+	693	WP_255817846.1	TrkA family potassium uptake protein	-
E4N74_RS11600 (E4N74_11895)	2504245..2504997	+	753	WP_255817848.1	hypothetical protein	-
E4N74_RS11605 (E4N74_11900)	2505078..2505473	-	396	WP_255817850.1	type II toxin-antitoxin system VapC family toxin	Toxin
E4N74_RS11610 (E4N74_11905)	2505473..2505703	-	231	WP_002692300.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E4N74_RS11615 (E4N74_11910)	2505884..2507656	+	1773	WP_255817852.1	ABC transporter ATP-binding protein	-
E4N74_RS11620 (E4N74_11915)	2507715..2508713	+	999	WP_255805377.1	MoxR family ATPase	-
E4N74_RS11625 (E4N74_11920)	2508676..2509974	-	1299	WP_255805378.1	hemolysin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15176.82 Da
• Isoelectric Point: 9.7944

>T123187 WP_255817850.1 NZ_CP038804:c2505473-2505078 [Treponema putidum]
MYLLDTNICIFLKNKKSPNVLHKIKEKKHLGIYISSITVAELQFGVYNSKYMERNRISLIKFLTPFSVLNFDDRDAEEFG
KIRTSLKNEGKIIGAYDMLIAAQALAKNLILVTDNTKEFCRIKNLTIEDWK

Nucleotide

• Length: 396 bp

>T123187 NZ_CP038804:c2505473-2505078 [Treponema putidum]
ATGTACCTATTGGATACAAATATCTGTATATTTCTTAAAAATAAAAAAAGTCCTAATGTACTTCACAAAATTAAAGAGAA
GAAACACTTGGGAATTTACATTTCAAGTATTACTGTGGCAGAGTTACAGTTCGGCGTATACAATAGTAAATATATGGAAA
GAAATAGAATATCATTAATAAAATTTTTAACACCTTTTTCTGTTTTAAATTTTGATGATAGAGATGCCGAGGAATTTGGA
AAAATAAGGACCAGCCTAAAAAATGAAGGGAAAATTATAGGAGCCTATGATATGTTGATAGCGGCACAGGCACTAGCGAA
AAATCTAATTCTTGTTACCGACAATACAAAAGAATTCTGCCGTATAAAAAACTTAACCATAGAAGATTGGAAATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8869.01 Da
• Isoelectric Point: 8.6367

>AT123187 WP_002692300.1 NZ_CP038804:c2505703-2505473 [Treponema putidum]
METAKLFQNGRSQAVRLPKKYNFSGTEVFIRRAGESVILFPKNREWETFLEGLNGFTDDFMEEGRNQPELQNRKGL

Nucleotide

• Length: 231 bp

>AT123187 NZ_CP038804:c2505703-2505473 [Treponema putidum]
ATGGAAACGGCAAAATTATTCCAAAACGGCAGGAGTCAAGCAGTTAGGCTGCCTAAAAAATATAATTTTTCGGGAACCGA
GGTTTTTATCCGCAGAGCCGGAGAGTCCGTTATTTTATTCCCAAAAAACAGGGAATGGGAAACCTTTTTAGAAGGCTTAA
ACGGTTTTACCGACGATTTTATGGAGGAAGGAAGAAACCAGCCTGAATTACAGAATCGGAAAGGTTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0F6MNP1