Detailed information of TA system TA123186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-DinJ
• Location: 1742415..1742940
• Replicon: chromosome
• Accession: NZ_CP038804
• Organism: Treponema putidum strain OMZ 835

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E4N74_RS08100
• Protein ID: WP_255804911.1
• Coordinates: 1742415..1742678 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E4N74_RS08105
• Protein ID: WP_255804913.1
• Coordinates: 1742683..1742940 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N74_RS08070 (E4N74_08310)	1738638..1739444	+	807	WP_245608945.1	hypothetical protein	-
E4N74_RS08075 (E4N74_08315)	1739485..1739997	-	513	WP_255804906.1	ClbS/DfsB family four-helix bundle protein	-
E4N74_RS08080 (E4N74_08320)	1740074..1740979	-	906	WP_255804907.1	YafY family protein	-
E4N74_RS08085 (E4N74_08325)	1741072..1741287	-	216	WP_044977525.1	hypothetical protein	-
E4N74_RS08090 (E4N74_08335)	1741631..1742038	-	408	WP_002686861.1	type II toxin-antitoxin system VapC family toxin	-
E4N74_RS08095 (E4N74_08340)	1742022..1742300	-	279	WP_044977527.1	hypothetical protein	-
E4N74_RS08100 (E4N74_08345)	1742415..1742678	-	264	WP_255804911.1	Txe/YoeB family addiction module toxin	Toxin
E4N74_RS08105 (E4N74_08350)	1742683..1742940	-	258	WP_255804913.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N74_RS08110 (E4N74_08355)	1743315..1744583	+	1269	WP_255804915.1	OmpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-50)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10510.08 Da
• Isoelectric Point: 9.4465

>T123186 WP_255804911.1 NZ_CP038804:c1742678-1742415 [Treponema putidum]
MIKAWDEDAWMDYVYWQTEDKKTLKRINMLIKDIERNGHNGLGSPEPLKENLSGFWSRRIDKKNRLVYRIVDNVIQIIQC
RTHYGEK

Nucleotide

• Length: 264 bp

>T123186 NZ_CP038804:c1742678-1742415 [Treponema putidum]
ATGATTAAAGCATGGGATGAAGATGCGTGGATGGATTATGTCTATTGGCAAACAGAAGATAAAAAAACATTAAAAAGAAT
CAATATGTTGATTAAAGATATAGAAAGAAATGGTCATAATGGCTTAGGCAGTCCTGAGCCATTAAAGGAAAATCTGTCAG
GATTCTGGAGCCGCAGGATCGATAAAAAAAATAGATTGGTTTATAGAATAGTCGATAATGTGATACAAATAATTCAGTGT
AGAACCCATTATGGTGAAAAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9880.42 Da
• Isoelectric Point: 9.5364

>AT123186 WP_255804913.1 NZ_CP038804:c1742940-1742683 [Treponema putidum]
MAQINVNIRMDSEVKQEAEQLFDSLGMNMTTAFNIFIRQSLRIGGIPFKIISDERGFYNKYNQKKLHAAAKRMNEGKYIV
HDILE

Nucleotide

• Length: 258 bp

>AT123186 NZ_CP038804:c1742940-1742683 [Treponema putidum]
ATGGCTCAAATAAATGTCAATATAAGAATGGATTCCGAAGTAAAACAAGAGGCTGAACAGCTTTTTGACAGTTTAGGAAT
GAATATGACAACTGCATTTAATATTTTCATTCGTCAATCATTAAGAATCGGCGGTATACCATTTAAAATTATAAGTGATG
AAAGAGGCTTTTATAATAAATATAATCAAAAAAAACTACATGCTGCTGCTAAAAGAATGAATGAAGGGAAATATATAGTG
CATGATATATTGGAATAG