Detailed information of TA system TA123184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 697790..698300
• Replicon: chromosome
• Accession: NZ_CP038804
• Organism: Treponema putidum strain OMZ 835

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E4N74_RS03290
• Protein ID: WP_255818851.1
• Coordinates: 698040..698300 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: E4N74_RS03285
• Protein ID: WP_255818849.1
• Coordinates: 697790..698047 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N74_RS03265 (E4N74_03380)	693009..694880	-	1872	WP_255818846.1	RNB domain-containing ribonuclease	-
E4N74_RS03270 (E4N74_03385)	694972..696843	-	1872	WP_255818847.1	hypothetical protein	-
E4N74_RS03275 (E4N74_03390)	697057..697341	+	285	WP_255818848.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
E4N74_RS03280 (E4N74_03395)	697331..697672	+	342	WP_049992356.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E4N74_RS03285 (E4N74_03400)	697790..698047	+	258	WP_255818849.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
E4N74_RS03290 (E4N74_03405)	698040..698300	+	261	WP_255818851.1	Txe/YoeB family addiction module toxin	Toxin
E4N74_RS03295 (E4N74_03410)	698410..698670	+	261	WP_002668741.1	DUF4160 domain-containing protein	-
E4N74_RS03300 (E4N74_03415)	698687..698989	+	303	WP_255818854.1	DUF2442 domain-containing protein	-
E4N74_RS03305 (E4N74_03420)	699049..699531	+	483	WP_255818872.1	pantetheine-phosphate adenylyltransferase	-
E4N74_RS03310 (E4N74_03425)	699555..699983	+	429	WP_255818873.1	hypothetical protein	-
E4N74_RS03315 (E4N74_03430)	700080..700289	+	210	WP_255818874.1	hypothetical protein	-
E4N74_RS03320 (E4N74_03435)	700276..700653	+	378	WP_255818876.1	type II toxin-antitoxin system VapC family toxin	-
E4N74_RS03325 (E4N74_03440)	700648..701295	-	648	WP_255818878.1	YoaK family protein	-
E4N74_RS03330 (E4N74_03445)	701370..701921	-	552	WP_255818880.1	hypothetical protein	-
E4N74_RS03335 (E4N74_03450)	701925..702542	-	618	WP_255818881.1	V-type ATP synthase subunit E	-
E4N74_RS03340 (E4N74_03455)	702687..703040	+	354	WP_044979057.1	metalloregulator ArsR/SmtB family transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10646.22 Da
• Isoelectric Point: 9.9262

>T123184 WP_255818851.1 NZ_CP038804:698040-698300 [Treponema putidum]
MNKLFTDEAWADYIYWFNTDKKVLKRINDLIKEIERTPFTGKGKPEPLKYSLSGYWSRRINHEHRIVYQVEKQQLVFISF
RYHYEK

Nucleotide

• Length: 261 bp

>T123184 NZ_CP038804:698040-698300 [Treponema putidum]
ATGAATAAACTCTTTACAGATGAGGCTTGGGCTGATTATATCTATTGGTTTAATACGGATAAAAAAGTTCTTAAAAGAAT
AAATGATTTGATAAAAGAAATCGAAAGAACGCCGTTTACGGGCAAGGGAAAACCGGAACCGTTAAAATATTCTTTGTCAG
GATATTGGTCAAGGCGGATAAATCATGAACATAGAATCGTATATCAAGTAGAAAAGCAGCAGTTAGTGTTTATTTCTTTT
AGGTACCACTATGAAAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9995.32 Da
• Isoelectric Point: 5.6342

>AT123184 WP_255818849.1 NZ_CP038804:697790-698047 [Treponema putidum]
MDAITYSDLRRNLKAYMDKVYNDYEPLIISRKNSENVVLLSVREYNSLIETDYLLKNEANAAHLIKSIEQHRAGKIQKHE
LLEDE

Nucleotide

• Length: 258 bp

>AT123184 NZ_CP038804:697790-698047 [Treponema putidum]
ATGGATGCAATTACATATTCGGATTTACGCCGCAATCTAAAAGCATATATGGACAAAGTTTACAATGACTATGAGCCCTT
GATAATATCAAGGAAAAATTCGGAAAATGTTGTTCTTCTATCGGTACGTGAGTATAATAGTCTTATTGAAACCGATTATT
TGCTTAAGAACGAGGCGAACGCAGCTCATTTAATAAAATCAATTGAGCAGCATAGAGCTGGGAAAATACAAAAACACGAG
TTGCTGGAAGATGAATAA