Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2661995..2662620 Replicon chromosome
Accession NZ_CP038803
Organism Treponema putidum strain OMZ 846

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4N75_RS12870 Protein ID WP_255805373.1
Coordinates 2661995..2662390 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4N75_RS12875 Protein ID WP_255822817.1
Coordinates 2662390..2662620 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N75_RS12850 (E4N75_12725) 2657868..2658704 + 837 WP_255822814.1 FAD-dependent thymidylate synthase -
E4N75_RS12855 (E4N75_12730) 2658723..2660447 + 1725 WP_255822815.1 TrkH family potassium uptake protein -
E4N75_RS12860 (E4N75_12735) 2660459..2661151 + 693 WP_255822816.1 TrkA family potassium uptake protein -
E4N75_RS12865 (E4N75_12740) 2661162..2661914 + 753 WP_044978310.1 hypothetical protein -
E4N75_RS12870 (E4N75_12745) 2661995..2662390 - 396 WP_255805373.1 type II toxin-antitoxin system VapC family toxin Toxin
E4N75_RS12875 (E4N75_12750) 2662390..2662620 - 231 WP_255822817.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4N75_RS12880 (E4N75_12755) 2662801..2664573 + 1773 WP_255822818.1 ABC transporter ATP-binding protein -
E4N75_RS12885 (E4N75_12760) 2664632..2665630 + 999 WP_255822819.1 MoxR family ATPase -
E4N75_RS12890 (E4N75_12765) 2665593..2666891 - 1299 WP_255822820.1 hemolysin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15153.74 Da        Isoelectric Point: 9.6131

>T123183 WP_255805373.1 NZ_CP038803:c2662390-2661995 [Treponema putidum]
MYLLDTNICIFLKNKKSPNVLQKIKENKHLGIYISSITVAELQFGVYNSKYMERNRISLIKFLTPFSVLNFDDRDAEEFG
KIRTSLKNEGKIIGAYDMLIAAQALAKNLILVTDNTKEFCRIKNLTIEDWK

Download         Length: 396 bp

>T123183 NZ_CP038803:c2662390-2661995 [Treponema putidum]
ATGTACTTATTGGATACAAATATCTGTATATTTCTTAAAAATAAAAAAAGTCCTAATGTACTTCAAAAAATCAAAGAGAA
TAAACACTTGGGAATTTACATTTCAAGTATTACCGTAGCAGAGTTACAGTTCGGCGTATACAATAGTAAATATATGGAAA
GAAATAGAATATCATTAATAAAATTTTTAACACCTTTTTCTGTTTTAAATTTTGATGATAGAGATGCCGAGGAATTTGGA
AAAATAAGGACCAGCCTAAAAAATGAAGGGAAAATTATAGGAGCCTATGATATGTTGATAGCGGCACAGGCACTAGCGAA
AAATCTAATTCTTGTTACCGACAATACAAAAGAATTCTGCCGTATAAAAAACTTAACCATAGAAGATTGGAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8869.99 Da        Isoelectric Point: 6.3368

>AT123183 WP_255822817.1 NZ_CP038803:c2662620-2662390 [Treponema putidum]
METAKLFQNGRSQAVRLPKKYNFSGTEVFIRRAGESVILFPKNREWETFLEGLNGFTDDFMEEGRNQPELQDRKGL

Download         Length: 231 bp

>AT123183 NZ_CP038803:c2662620-2662390 [Treponema putidum]
ATGGAAACGGCAAAATTATTCCAAAACGGCAGGAGTCAAGCAGTTAGGCTGCCTAAAAAATATAATTTTTCGGGAACCGA
GGTTTTTATCCGCAGAGCCGGAGAGTCCGTTATTTTATTCCCCAAAAACAGGGAATGGGAAACATTTTTAGAAGGCTTAA
ACGGTTTTACCGACGATTTTATGGAGGAAGGAAGAAACCAGCCTGAATTACAGGATAGGAAAGGTTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References