Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-DinJ
Location 1842771..1843296 Replicon chromosome
Accession NZ_CP038803
Organism Treponema putidum strain OMZ 846

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag E4N75_RS08825 Protein ID WP_255804911.1
Coordinates 1842771..1843034 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E4N75_RS08830 Protein ID WP_255804913.1
Coordinates 1843039..1843296 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N75_RS08780 (E4N75_08730) 1838359..1839228 - 870 WP_255822428.1 radical SAM protein -
E4N75_RS08785 (E4N75_08735) 1839261..1839773 - 513 WP_255822429.1 ClbS/DfsB family four-helix bundle protein -
E4N75_RS08790 (E4N75_08740) 1839906..1840814 - 909 WP_255822430.1 YafY family protein -
E4N75_RS08795 (E4N75_08745) 1840830..1841234 - 405 WP_255822431.1 type II toxin-antitoxin system VapC family toxin -
E4N75_RS08800 (E4N75_08750) 1841234..1841473 - 240 WP_255822432.1 DUF2281 domain-containing protein -
E4N75_RS08805 (E4N75_08755) 1841564..1841662 + 99 WP_255822433.1 type II toxin-antitoxin system YoeB family toxin -
E4N75_RS08810 (E4N75_08760) 1841703..1842110 - 408 WP_255822434.1 type II toxin-antitoxin system VapC family toxin -
E4N75_RS08815 (E4N75_08765) 1842094..1842276 - 183 WP_255822435.1 hypothetical protein -
E4N75_RS08820 1842363..1842560 - 198 WP_255822436.1 alpha/beta hydrolase -
E4N75_RS08825 (E4N75_08775) 1842771..1843034 - 264 WP_255804911.1 Txe/YoeB family addiction module toxin Toxin
E4N75_RS08830 (E4N75_08780) 1843039..1843296 - 258 WP_255804913.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E4N75_RS08835 (E4N75_08785) 1843671..1844939 + 1269 WP_255822437.1 OmpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-50)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10510.08 Da        Isoelectric Point: 9.4465

>T123182 WP_255804911.1 NZ_CP038803:c1843034-1842771 [Treponema putidum]
MIKAWDEDAWMDYVYWQTEDKKTLKRINMLIKDIERNGHNGLGSPEPLKENLSGFWSRRIDKKNRLVYRIVDNVIQIIQC
RTHYGEK

Download         Length: 264 bp

>T123182 NZ_CP038803:c1843034-1842771 [Treponema putidum]
ATGATTAAAGCATGGGATGAAGATGCGTGGATGGATTATGTCTATTGGCAAACAGAAGATAAAAAAACATTAAAAAGAAT
CAATATGTTGATTAAAGATATAGAAAGAAATGGTCATAATGGCTTAGGCAGTCCTGAGCCATTAAAGGAAAATCTGTCAG
GATTCTGGAGCCGCAGGATCGATAAAAAAAATAGATTGGTTTATAGAATAGTCGATAATGTGATACAAATAATTCAGTGT
AGAACCCATTATGGTGAAAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9880.42 Da        Isoelectric Point: 9.5364

>AT123182 WP_255804913.1 NZ_CP038803:c1843296-1843039 [Treponema putidum]
MAQINVNIRMDSEVKQEAEQLFDSLGMNMTTAFNIFIRQSLRIGGIPFKIISDERGFYNKYNQKKLHAAAKRMNEGKYIV
HDILE

Download         Length: 258 bp

>AT123182 NZ_CP038803:c1843296-1843039 [Treponema putidum]
ATGGCTCAAATAAATGTCAATATAAGAATGGATTCCGAAGTAAAACAAGAGGCTGAACAGCTTTTTGACAGTTTAGGAAT
GAATATGACAACTGCATTTAATATTTTCATTCGTCAATCATTAAGAATCGGCGGTATACCATTTAAAATTATAAGTGATG
AAAGAGGCTTTTATAATAAATATAATCAAAAAAAACTACATGCTGCTGCTAAAAGAATGAATGAAGGGAAATATATAGTG
CATGATATATTGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References