Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 762820..763330 Replicon chromosome
Accession NZ_CP038803
Organism Treponema putidum strain OMZ 846

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E4N75_RS03655 Protein ID WP_255823919.1
Coordinates 763070..763330 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag E4N75_RS03650 Protein ID WP_255806139.1
Coordinates 762820..763077 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N75_RS03630 (E4N75_03645) 758039..759910 - 1872 WP_255823916.1 RNB domain-containing ribonuclease -
E4N75_RS03635 (E4N75_03650) 760002..761873 - 1872 WP_255823917.1 hypothetical protein -
E4N75_RS03640 (E4N75_03655) 762087..762371 + 285 WP_044979047.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
E4N75_RS03645 (E4N75_03660) 762361..762702 + 342 WP_049992356.1 type II toxin-antitoxin system RelE/ParE family toxin -
E4N75_RS03650 (E4N75_03665) 762820..763077 + 258 WP_255806139.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
E4N75_RS03655 (E4N75_03670) 763070..763330 + 261 WP_255823919.1 Txe/YoeB family addiction module toxin Toxin
E4N75_RS03660 (E4N75_03675) 763440..763700 + 261 WP_002668741.1 DUF4160 domain-containing protein -
E4N75_RS03665 (E4N75_03680) 763717..764019 + 303 WP_255818854.1 DUF2442 domain-containing protein -
E4N75_RS03670 (E4N75_03685) 764079..764561 + 483 WP_255823921.1 pantetheine-phosphate adenylyltransferase -
E4N75_RS03675 (E4N75_03690) 764587..765015 + 429 WP_255823922.1 hypothetical protein -
E4N75_RS03680 (E4N75_03695) 764976..765473 - 498 WP_255823923.1 type II toxin-antitoxin system HicB family antitoxin -
E4N75_RS03685 765725..766753 - 1029 WP_255823924.1 ABC transporter ATP-binding protein -
E4N75_RS03690 766750..767508 - 759 WP_255823925.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10688.26 Da        Isoelectric Point: 9.9450

>T123180 WP_255823919.1 NZ_CP038803:763070-763330 [Treponema putidum]
MNKLFTDEAWADYIYWFNTDRKILKRINDLIKEIERTPFTGKGKPEPLKYSLSGYWSRRINHEHRIVYQVEKQQLVFISF
RYHYEK

Download         Length: 261 bp

>T123180 NZ_CP038803:763070-763330 [Treponema putidum]
ATGAATAAACTCTTTACAGATGAGGCTTGGGCTGATTATATCTATTGGTTTAATACGGATAGAAAAATTCTTAAAAGAAT
AAATGATTTGATAAAAGAAATCGAAAGAACGCCGTTTACGGGCAAGGGAAAACCGGAACCGTTAAAATATTCTTTGTCAG
GATATTGGTCAAGGCGGATAAATCATGAACATAGAATCGTATATCAAGTAGAAAAGCAGCAGTTAGTGTTTATTTCTTTT
AGGTACCACTATGAAAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9976.27 Da        Isoelectric Point: 5.5693

>AT123180 WP_255806139.1 NZ_CP038803:762820-763077 [Treponema putidum]
MDAITYSDLRRNLKAYMDKVYNDYEPLIISRKNSENVVLLSVHEYNSLIETDYLLKNEANAAHLIKSIEQHRAGKIQKHE
LLEDE

Download         Length: 258 bp

>AT123180 NZ_CP038803:762820-763077 [Treponema putidum]
ATGGATGCAATTACATATTCGGATTTACGCCGCAATCTAAAAGCATATATGGACAAAGTTTACAATGACTATGAGCCTTT
GATAATATCAAGGAAAAATTCGGAAAATGTTGTTCTTTTATCTGTACATGAGTATAATAGTCTTATTGAAACCGATTATT
TGCTTAAGAACGAGGCGAACGCAGCTCATTTAATAAAATCAATTGAGCAGCATAGAGCAGGGAAAATACAAAAACACGAG
TTGCTGGAAGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References