Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2699346..2699971 Replicon chromosome
Accession NZ_CP038802
Organism Treponema putidum strain OMZ 847

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4N76_RS12745 Protein ID WP_255805373.1
Coordinates 2699346..2699741 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4N76_RS12750 Protein ID WP_255805374.1
Coordinates 2699741..2699971 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N76_RS12725 (E4N76_12915) 2695226..2696062 + 837 WP_255805370.1 FAD-dependent thymidylate synthase -
E4N76_RS12730 (E4N76_12920) 2696074..2697798 + 1725 WP_255805371.1 TrkH family potassium uptake protein -
E4N76_RS12735 (E4N76_12925) 2697810..2698502 + 693 WP_255805372.1 TrkA family potassium uptake protein -
E4N76_RS12740 (E4N76_12930) 2698513..2699265 + 753 WP_044978310.1 hypothetical protein -
E4N76_RS12745 (E4N76_12935) 2699346..2699741 - 396 WP_255805373.1 type II toxin-antitoxin system VapC family toxin Toxin
E4N76_RS12750 (E4N76_12940) 2699741..2699971 - 231 WP_255805374.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4N76_RS12755 2700153..2700716 + 564 WP_255805375.1 hypothetical protein -
E4N76_RS12760 (E4N76_12945) 2700720..2701925 + 1206 WP_255805376.1 ABC transporter ATP-binding protein -
E4N76_RS12765 (E4N76_12950) 2701984..2702982 + 999 WP_255805377.1 MoxR family ATPase -
E4N76_RS12770 (E4N76_12955) 2702945..2704243 - 1299 WP_255805378.1 hemolysin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15153.74 Da        Isoelectric Point: 9.6131

>T123179 WP_255805373.1 NZ_CP038802:c2699741-2699346 [Treponema putidum]
MYLLDTNICIFLKNKKSPNVLQKIKENKHLGIYISSITVAELQFGVYNSKYMERNRISLIKFLTPFSVLNFDDRDAEEFG
KIRTSLKNEGKIIGAYDMLIAAQALAKNLILVTDNTKEFCRIKNLTIEDWK

Download         Length: 396 bp

>T123179 NZ_CP038802:c2699741-2699346 [Treponema putidum]
ATGTACTTATTGGATACAAATATCTGTATATTTCTTAAAAATAAAAAAAGTCCTAATGTACTTCAAAAAATCAAAGAGAA
TAAACACTTGGGAATTTACATTTCAAGTATTACCGTAGCAGAGTTACAGTTCGGCGTATACAATAGTAAATATATGGAAA
GAAATAGAATATCATTAATAAAATTTTTAACACCTTTTTCTGTTTTAAATTTTGATGATAGAGATGCCGAGGAATTTGGA
AAAATAAGGACCAGCCTAAAAAATGAAGGGAAAATTATAGGAGCCTATGATATGTTGATAGCGGCACAGGCACTAGCGAA
AAATCTAATTCTTGTTACCGACAATACAAAAGAATTCTGCCGTATAAAAAACTTAACCATAGAAGATTGGAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8827.95 Da        Isoelectric Point: 6.3293

>AT123179 WP_255805374.1 NZ_CP038802:c2699971-2699741 [Treponema putidum]
METAKLFQNGRSQAVRLPKKYNFSGTEVFIRRAGDSVILFPKNKEWETFLEGLNGFTDDFMEEGRNQPELQDRKGL

Download         Length: 231 bp

>AT123179 NZ_CP038802:c2699971-2699741 [Treponema putidum]
ATGGAAACGGCAAAATTATTCCAAAACGGCAGGAGTCAAGCAGTTAGGCTGCCTAAAAAATATAATTTTTCGGGAACCGA
GGTTTTTATCCGCAGAGCCGGAGATTCCGTTATTTTATTCCCCAAAAACAAGGAATGGGAAACATTTTTAGAAGGCTTAA
ACGGTTTTACCGACGATTTTATGGAGGAAGGAAGAAACCAGCCTGAATTACAGGATAGGAAAGGTTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References