Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 1012065..1012630 | Replicon | chromosome |
| Accession | NZ_CP038802 | ||
| Organism | Treponema putidum strain OMZ 847 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | E4N76_RS04965 | Protein ID | WP_255806270.1 |
| Coordinates | 1012292..1012630 (+) | Length | 113 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | A0A562SC65 |
| Locus tag | E4N76_RS04960 | Protein ID | WP_044979179.1 |
| Coordinates | 1012065..1012298 (+) | Length | 78 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E4N76_RS04930 (E4N76_04980) | 1007533..1008021 | + | 489 | WP_255806268.1 | DUF1353 domain-containing protein | - |
| E4N76_RS04935 (E4N76_04985) | 1008536..1008910 | + | 375 | WP_145475200.1 | hypothetical protein | - |
| E4N76_RS04940 (E4N76_04990) | 1009062..1009760 | + | 699 | WP_010690396.1 | hypothetical protein | - |
| E4N76_RS04945 (E4N76_04995) | 1009955..1010662 | + | 708 | WP_255806269.1 | hypothetical protein | - |
| E4N76_RS04950 (E4N76_05000) | 1010807..1011115 | + | 309 | WP_255806249.1 | nucleotidyltransferase family protein | - |
| E4N76_RS04955 (E4N76_05005) | 1011099..1011455 | + | 357 | WP_044979178.1 | DUF86 domain-containing protein | - |
| E4N76_RS04960 (E4N76_05010) | 1012065..1012298 | + | 234 | WP_044979179.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| E4N76_RS04965 (E4N76_05015) | 1012292..1012630 | + | 339 | WP_255806270.1 | endoribonuclease MazF | Toxin |
| E4N76_RS04970 (E4N76_05020) | 1012776..1013084 | + | 309 | WP_255806249.1 | nucleotidyltransferase family protein | - |
| E4N76_RS04975 (E4N76_05025) | 1013068..1013418 | + | 351 | WP_255806271.1 | DUF86 domain-containing protein | - |
| E4N76_RS04980 (E4N76_05030) | 1013408..1014067 | + | 660 | WP_255806272.1 | hypothetical protein | - |
| E4N76_RS04985 (E4N76_05035) | 1014234..1014488 | + | 255 | WP_255806263.1 | hypothetical protein | - |
| E4N76_RS04990 (E4N76_05040) | 1015475..1015687 | + | 213 | WP_255806273.1 | toxin | - |
| E4N76_RS04995 (E4N76_05045) | 1015680..1015937 | + | 258 | WP_255806274.1 | hypothetical protein | - |
| E4N76_RS05000 (E4N76_05050) | 1016298..1016558 | + | 261 | WP_255806275.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| E4N76_RS05005 (E4N76_05055) | 1016558..1016824 | + | 267 | WP_255806276.1 | Txe/YoeB family addiction module toxin | - |
| E4N76_RS05010 (E4N76_05060) | 1016975..1017283 | + | 309 | WP_255806249.1 | nucleotidyltransferase family protein | - |
| E4N76_RS05015 (E4N76_05065) | 1017267..1017623 | + | 357 | WP_044979178.1 | DUF86 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 975119..1028183 | 53064 | |
| - | inside | Integron | - | - | 972962..1021657 | 48695 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 113 a.a. Molecular weight: 12866.70 Da Isoelectric Point: 6.2183
>T123177 WP_255806270.1 NZ_CP038802:1012292-1012630 [Treponema putidum]
MVNSNYVPDRGDLVWLDFTPQEGHEQKGRRPAICISQKRYNQKVGLALFCPITSHIKGYPFEIVLDNHSINGCILSDQVK
NLDYKKRSCDFIEKTTEEEINAVVDNIKLLIE
MVNSNYVPDRGDLVWLDFTPQEGHEQKGRRPAICISQKRYNQKVGLALFCPITSHIKGYPFEIVLDNHSINGCILSDQVK
NLDYKKRSCDFIEKTTEEEINAVVDNIKLLIE
Download Length: 339 bp
>T123177 NZ_CP038802:1012292-1012630 [Treponema putidum]
ATGGTGAATTCAAATTATGTTCCCGATAGAGGCGATTTAGTTTGGCTTGATTTTACCCCGCAAGAAGGACATGAGCAGAA
AGGTCGTCGTCCTGCAATTTGCATTTCTCAAAAACGATACAATCAAAAAGTCGGACTTGCTTTATTTTGTCCTATTACAA
GCCATATAAAAGGCTATCCTTTTGAAATTGTATTGGATAATCATTCGATAAATGGCTGTATTCTTAGCGACCAAGTAAAG
AACCTTGATTATAAAAAAAGAAGTTGTGATTTTATAGAAAAAACAACAGAAGAAGAGATAAATGCTGTTGTAGATAATAT
AAAGTTGTTGATTGAATAA
ATGGTGAATTCAAATTATGTTCCCGATAGAGGCGATTTAGTTTGGCTTGATTTTACCCCGCAAGAAGGACATGAGCAGAA
AGGTCGTCGTCCTGCAATTTGCATTTCTCAAAAACGATACAATCAAAAAGTCGGACTTGCTTTATTTTGTCCTATTACAA
GCCATATAAAAGGCTATCCTTTTGAAATTGTATTGGATAATCATTCGATAAATGGCTGTATTCTTAGCGACCAAGTAAAG
AACCTTGATTATAAAAAAAGAAGTTGTGATTTTATAGAAAAAACAACAGAAGAAGAGATAAATGCTGTTGTAGATAATAT
AAAGTTGTTGATTGAATAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8588.81 Da Isoelectric Point: 5.0035
>AT123177 WP_044979179.1 NZ_CP038802:1012065-1012298 [Treponema putidum]
MQVVVQKWGNSLGFRIPSLWAKDNNVKNGSKIEVIAEKGKIVILPQEKTLDDMLAMVTSENVHSEISTGYSVGNEEW
MQVVVQKWGNSLGFRIPSLWAKDNNVKNGSKIEVIAEKGKIVILPQEKTLDDMLAMVTSENVHSEISTGYSVGNEEW
Download Length: 234 bp
>AT123177 NZ_CP038802:1012065-1012298 [Treponema putidum]
ATGCAGGTTGTAGTTCAGAAATGGGGTAATAGTCTCGGGTTTAGAATACCCTCTCTTTGGGCAAAAGATAATAATGTAAA
GAATGGAAGCAAAATAGAAGTAATCGCAGAAAAAGGAAAAATAGTAATTCTTCCTCAGGAAAAAACCCTTGATGATATGC
TGGCAATGGTTACTTCTGAAAATGTTCATTCGGAAATCTCTACAGGTTATTCAGTAGGTAACGAAGAATGGTGA
ATGCAGGTTGTAGTTCAGAAATGGGGTAATAGTCTCGGGTTTAGAATACCCTCTCTTTGGGCAAAAGATAATAATGTAAA
GAATGGAAGCAAAATAGAAGTAATCGCAGAAAAAGGAAAAATAGTAATTCTTCCTCAGGAAAAAACCCTTGATGATATGC
TGGCAATGGTTACTTCTGAAAATGTTCATTCGGAAATCTCTACAGGTTATTCAGTAGGTAACGAAGAATGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|