Detailed information of TA system TA123176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 826492..827002
• Replicon: chromosome
• Accession: NZ_CP038802
• Organism: Treponema putidum strain OMZ 847

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E4N76_RS04030
• Protein ID: WP_255806140.1
• Coordinates: 826742..827002 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: E4N76_RS04025
• Protein ID: WP_255806139.1
• Coordinates: 826492..826749 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N76_RS04005 (E4N76_04075)	821711..823582	-	1872	WP_255806137.1	RNB domain-containing ribonuclease	-
E4N76_RS04010 (E4N76_04080)	823674..825545	-	1872	WP_255806138.1	hypothetical protein	-
E4N76_RS04015 (E4N76_04085)	825759..826043	+	285	WP_044979047.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
E4N76_RS04020 (E4N76_04090)	826033..826374	+	342	WP_049992356.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E4N76_RS04025 (E4N76_04095)	826492..826749	+	258	WP_255806139.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
E4N76_RS04030 (E4N76_04100)	826742..827002	+	261	WP_255806140.1	Txe/YoeB family addiction module toxin	Toxin
E4N76_RS04035 (E4N76_04105)	827071..827547	+	477	WP_255806141.1	pantetheine-phosphate adenylyltransferase	-
E4N76_RS04040 (E4N76_04110)	827577..828005	+	429	WP_255806142.1	hypothetical protein	-
E4N76_RS04045 (E4N76_04115)	827966..828355	-	390	WP_255806143.1	type II toxin-antitoxin system HicB family antitoxin	-
E4N76_RS04050	828352..828462	-	111	WP_253697691.1	type II toxin-antitoxin system HicA family toxin	-
E4N76_RS04055 (E4N76_04120)	828520..829164	-	645	WP_255806144.1	YoaK family protein	-
E4N76_RS04060 (E4N76_04125)	829191..829742	-	552	WP_255806145.1	DUF2764 domain-containing protein	-
E4N76_RS04065 (E4N76_04130)	829746..830363	-	618	WP_255806146.1	V-type ATP synthase subunit E	-
E4N76_RS04070 (E4N76_04135)	830508..830861	+	354	WP_044979057.1	metalloregulator ArsR/SmtB family transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10633.18 Da
• Isoelectric Point: 9.7694

>T123176 WP_255806140.1 NZ_CP038802:826742-827002 [Treponema putidum]
MNKLFTDEAWADYIYWFNTDKKVLKRINDLIKEIERTPFTGKGKPEPLKYSLSGYWSRRINHEHRIVYQVETQQLLFISF
RYHYEK

Nucleotide

• Length: 261 bp

>T123176 NZ_CP038802:826742-827002 [Treponema putidum]
ATGAATAAACTCTTTACAGATGAGGCTTGGGCTGATTATATCTATTGGTTTAATACGGATAAAAAAGTTCTTAAAAGAAT
AAATGATTTGATAAAAGAAATCGAAAGAACGCCGTTTACGGGCAAGGGAAAACCGGAACCGTTAAAATATTCTTTGTCAG
GATATTGGTCAAGACGGATAAATCATGAACATAGAATCGTATATCAGGTAGAAACGCAGCAGCTATTGTTTATTTCTTTT
AGGTACCACTATGAAAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9976.27 Da
• Isoelectric Point: 5.5693

>AT123176 WP_255806139.1 NZ_CP038802:826492-826749 [Treponema putidum]
MDAITYSDLRRNLKAYMDKVYNDYEPLIISRKNSENVVLLSVHEYNSLIETDYLLKNEANAAHLIKSIEQHRAGKIQKHE
LLEDE

Nucleotide

• Length: 258 bp

>AT123176 NZ_CP038802:826492-826749 [Treponema putidum]
ATGGATGCAATTACATATTCGGATTTACGCCGCAATCTAAAAGCATATATGGACAAAGTTTACAATGACTATGAGCCTTT
GATAATATCAAGGAAAAATTCGGAAAATGTTGTTCTTTTATCTGTACATGAGTATAATAGTCTTATTGAAACCGATTATT
TGCTTAAGAACGAGGCGAACGCAGCTCATTTAATAAAATCAATTGAGCAGCATAGAGCAGGGAAAATACAAAAACACGAG
TTGCTGGAAGATGAATAA