Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2073350..2073900 Replicon chromosome
Accession NZ_CP038801
Organism Treponema denticola strain ATCC 700771

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E4N77_RS09755 Protein ID WP_253698329.1
Coordinates 2073619..2073900 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E4N77_RS09750 Protein ID WP_255802901.1
Coordinates 2073350..2073622 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N77_RS09710 (E4N77_10000) 2068369..2068836 - 468 WP_002685268.1 flavodoxin domain-containing protein -
E4N77_RS09715 (E4N77_10005) 2068913..2069368 - 456 WP_255802898.1 DUF2004 domain-containing protein -
E4N77_RS09720 (E4N77_10010) 2069458..2070123 - 666 WP_002665889.1 DUF4272 domain-containing protein -
E4N77_RS09725 (E4N77_10015) 2070260..2071756 + 1497 WP_255802899.1 carboxylesterase family protein -
E4N77_RS09730 (E4N77_10020) 2071774..2071998 + 225 Protein_1900 SMI1/KNR4 family protein -
E4N77_RS09735 (E4N77_10025) 2072032..2072490 + 459 WP_255802900.1 hypothetical protein -
E4N77_RS09740 (E4N77_10030) 2072516..2073085 + 570 WP_253696286.1 hypothetical protein -
E4N77_RS09745 (E4N77_10035) 2073090..2073284 + 195 WP_253696288.1 hypothetical protein -
E4N77_RS09750 (E4N77_10040) 2073350..2073622 + 273 WP_255802901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E4N77_RS09755 (E4N77_10045) 2073619..2073900 + 282 WP_253698329.1 type II toxin-antitoxin system YafQ family toxin Toxin
E4N77_RS09760 (E4N77_10050) 2073928..2074245 + 318 WP_253696290.1 hypothetical protein -
E4N77_RS09765 (E4N77_10055) 2074262..2074381 + 120 WP_255804650.1 DUF2262 domain-containing protein -
E4N77_RS09770 (E4N77_10060) 2074553..2074855 + 303 WP_253696294.1 hypothetical protein -
E4N77_RS09775 (E4N77_10065) 2074955..2075893 + 939 WP_253696296.1 Fic family protein -
E4N77_RS09780 (E4N77_10075) 2076050..2076598 + 549 WP_255802902.1 hypothetical protein -
E4N77_RS09785 (E4N77_10080) 2076742..2076960 + 219 WP_255802903.1 helix-turn-helix transcriptional regulator -
E4N77_RS09790 (E4N77_10085) 2077090..2077419 + 330 WP_255802904.1 HipA N-terminal domain-containing protein -
E4N77_RS09795 (E4N77_10090) 2077416..2078366 + 951 WP_255802905.1 HipA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11123.96 Da        Isoelectric Point: 9.8188

>T123173 WP_253698329.1 NZ_CP038801:2073619-2073900 [Treponema denticola]
IKYEIKFTNQFKKDIRLAKKQNKNLDKLLKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Download         Length: 282 bp

>T123173 NZ_CP038801:2073619-2073900 [Treponema denticola]
ATAAAATACGAAATAAAATTTACAAACCAATTTAAGAAAGATATTAGACTTGCAAAAAAACAGAATAAAAACTTAGATAA
GTTATTGAAAGTTATTGATTTACTTTCAAATGGAGAAAAACTTGAAGCTAAGTATAGAGATCATGATTTATCAGGAAACT
ATAAGGGAACAAGAGAATGTCACATAGAACCGGATTGGCTTTTAGTATATGAAATTAGAAATGATGTACTTGTACTTATG
CTTTATAGACTTGGCTCACATTCAGAGCTTTTTAAAAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10204.84 Da        Isoelectric Point: 8.5046

>AT123173 WP_255802901.1 NZ_CP038801:2073350-2073622 [Treponema denticola]
MATTNLNIRTDKEMKKRAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Download         Length: 273 bp

>AT123173 NZ_CP038801:2073350-2073622 [Treponema denticola]
ATGGCAACAACAAATTTGAATATCAGAACAGATAAAGAAATGAAGAAGCGAGCAGAAGCTATTTTTTTTGAGTTAGGGCT
TAATATGACAACGGCTATCAATATATTTTTAAGAACAACTATTAGAGAAAATGGAATTCCGTTTGCTTTGAAATTAGATA
TTCCCAATGCAATTACAGCGTCGGCAATAGAAGAAGGTAGAAAAATTGCTTATGATGATACCGTAAAAAAATATTCAAAT
ATAGACGATTTGCGGAAAGCACTGGAAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References