123172

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1524554..1525164 Replicon chromosome
Accession NZ_CP038801
Organism Treponema denticola strain ATCC 700771

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E4N77_RS07240 Protein ID WP_253695476.1
Coordinates 1524554..1524847 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E4N77_RS07245 Protein ID WP_253695478.1
Coordinates 1524850..1525164 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N77_RS07220 (E4N77_07365) 1520527..1521240 - 714 WP_255802460.1 tRNA threonylcarbamoyladenosine dehydratase -
E4N77_RS07225 (E4N77_07370) 1521260..1522318 - 1059 WP_255802461.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
E4N77_RS07230 (E4N77_07375) 1522395..1523141 + 747 WP_255802462.1 DUF368 domain-containing protein -
E4N77_RS07235 (E4N77_07380) 1523252..1524514 + 1263 WP_255802463.1 uracil permease -
E4N77_RS07240 (E4N77_07385) 1524554..1524847 + 294 WP_253695476.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4N77_RS07245 (E4N77_07390) 1524850..1525164 + 315 WP_253695478.1 putative addiction module antidote protein Antitoxin
E4N77_RS07250 (E4N77_07395) 1525208..1525870 + 663 WP_255802464.1 C39 family peptidase -
E4N77_RS07255 (E4N77_07400) 1525922..1527103 - 1182 WP_255802465.1 YibE/F family protein -
E4N77_RS07260 (E4N77_07405) 1527219..1528820 - 1602 WP_255802466.1 5'-nucleotidase C-terminal domain-containing protein -
E4N77_RS07265 (E4N77_07410) 1528885..1530135 - 1251 WP_255802467.1 peptidase U32 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11484.58 Da        Isoelectric Point: 10.2475

>T123172 WP_253695476.1 NZ_CP038801:1524554-1524847 [Treponema denticola]
MIEIEKTDIYQKWLENLRDRKAKIIITARIKRLQMGNFGDCKFINKKIYELRINYAKGYRVYFINKNNKIILLLLGGDKS
TQTKDIQKAIDMAEELA

Download         Length: 294 bp

>T123172 NZ_CP038801:1524554-1524847 [Treponema denticola]
ATGATTGAGATCGAAAAAACAGATATCTATCAAAAGTGGCTTGAAAACTTAAGAGATAGAAAAGCCAAAATTATTATTAC
AGCCAGAATCAAAAGGCTTCAGATGGGTAATTTCGGCGATTGTAAGTTTATCAACAAAAAGATATATGAACTTCGAATCA
ATTATGCAAAAGGTTATAGGGTTTATTTTATTAATAAAAATAACAAAATTATTTTACTCCTTTTGGGTGGAGACAAATCT
ACACAAACCAAAGATATACAGAAAGCCATAGACATGGCTGAGGAGCTCGCATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11761.73 Da        Isoelectric Point: 8.4123

>AT123172 WP_253695478.1 NZ_CP038801:1524850-1525164 [Treponema denticola]
MKISKWDAADYLKTRKDIAIYLDEILKIAREDNMPELFIEALGDVTRAQGMTDLAKTIDVSRESLYKSLSKKGNPSFSTI
FKVLEFLNLEMSIAAPKTLKQASM

Download         Length: 315 bp

>AT123172 NZ_CP038801:1524850-1525164 [Treponema denticola]
ATGAAAATATCAAAATGGGACGCAGCAGATTATCTTAAAACAAGAAAAGATATTGCAATATACTTAGATGAAATACTAAA
AATTGCAAGAGAAGATAATATGCCGGAACTATTTATAGAAGCCCTTGGAGATGTAACCAGAGCTCAAGGAATGACGGATC
TAGCAAAAACAATAGATGTCAGTAGAGAAAGTCTTTATAAATCGCTATCAAAAAAAGGGAATCCATCTTTTTCAACAATC
TTTAAAGTTCTTGAATTTCTTAATTTAGAAATGAGCATCGCTGCCCCAAAAACTTTAAAACAAGCAAGCATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References