Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 11271..11896 Replicon chromosome
Accession NZ_CP038800
Organism Treponema denticola strain ATCC 700768

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4N78_RS00055 Protein ID WP_255811097.1
Coordinates 11271..11666 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4N78_RS00060 Protein ID WP_255811098.1
Coordinates 11666..11896 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N78_RS00035 (E4N78_00035) 6786..7418 + 633 WP_255811093.1 ABC transporter ATP-binding protein -
E4N78_RS00040 (E4N78_00040) 7422..8630 - 1209 WP_255811094.1 ATP-binding protein -
E4N78_RS00045 (E4N78_00045) 8785..9873 - 1089 WP_255811095.1 Fic family protein -
E4N78_RS00050 (E4N78_00050) 9945..11153 - 1209 WP_255811096.1 M20 family metallopeptidase -
E4N78_RS00055 (E4N78_00055) 11271..11666 - 396 WP_255811097.1 type II toxin-antitoxin system VapC family toxin Toxin
E4N78_RS00060 (E4N78_00060) 11666..11896 - 231 WP_255811098.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4N78_RS00065 (E4N78_00065) 12028..12195 + 168 WP_255811099.1 hypothetical protein -
E4N78_RS00070 (E4N78_00070) 12231..12509 - 279 WP_255811100.1 type II toxin-antitoxin system YafQ family toxin -
E4N78_RS00075 (E4N78_00075) 12502..12768 - 267 WP_255811101.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
E4N78_RS00080 (E4N78_00080) 12984..14573 - 1590 WP_255811102.1 ABC transporter ATP-binding protein -
E4N78_RS00085 (E4N78_00085) 14820..15200 + 381 WP_253681125.1 DUF2089 domain-containing protein -
E4N78_RS00090 (E4N78_00090) 15246..15560 + 315 WP_002692308.1 hypothetical protein -
E4N78_RS00095 (E4N78_00095) 15624..16643 + 1020 WP_255811103.1 MoxR family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 15122.86 Da        Isoelectric Point: 9.9508

>T123171 WP_255811097.1 NZ_CP038800:c11666-11271 [Treponema denticola]
MYLLDTNICIFLKIKKSPNVLQKIKKNKHLGIYISSITVAELQFGVYNSKYMERNRIALIKFLTPFSVLNFDDRDAEEFG
KIRTSLKNEGKIIGAYDMLIAAQALAKNLILVTDNTKEFCRIKTLTIEDWK

Download         Length: 396 bp

>T123171 NZ_CP038800:c11666-11271 [Treponema denticola]
ATGTACCTATTGGATACAAATATCTGTATATTTCTTAAAATTAAAAAAAGTCCTAATGTACTTCAAAAAATCAAAAAGAA
TAAACACTTAGGAATTTACATTTCAAGTATTACTGTGGCAGAGTTACAGTTCGGCGTATACAATAGTAAATATATGGAAA
GAAATAGAATAGCATTAATAAAATTTTTAACACCTTTTTCTGTTTTAAATTTTGATGATAGAGATGCCGAAGAATTCGGG
AAAATAAGGACCAGCCTAAAAAATGAAGGGAAAATTATCGGAGCCTATGATATGTTGATAGCGGCACAGGCTCTAGCTAA
AAATCTAATTCTCGTTACCGATAATACAAAAGAATTCTGCCGTATAAAAACCTTAACCATAGAAGATTGGAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8828.00 Da        Isoelectric Point: 8.6155

>AT123171 WP_255811098.1 NZ_CP038800:c11896-11666 [Treponema denticola]
METAKLFQNGRSQAVRLPKKYNFSGTEVFIRRAGESVILFPKNKEWETFLEGLNGFTDDFMEEGRTQPELQNRKGL

Download         Length: 231 bp

>AT123171 NZ_CP038800:c11896-11666 [Treponema denticola]
ATGGAAACGGCAAAATTATTCCAAAACGGCAGGAGTCAAGCAGTTAGGCTGCCTAAAAAATATAATTTTTCGGGAACCGA
GGTTTTTATCCGCAGAGCCGGAGAGTCCGTTATTTTATTCCCCAAAAACAAGGAATGGGAAACATTTTTAGAAGGCTTAA
ACGGTTTTACCGACGATTTTATGGAGGAAGGAAGAACCCAGCCTGAATTACAGAATCGGAAAGGTTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References