Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4618408..4619206 Replicon chromosome
Accession NZ_CP038791
Organism Escherichia coli strain PF9285

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8S7MZH4
Locus tag E5M00_RS23100 Protein ID WP_001094453.1
Coordinates 4618829..4619206 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag E5M00_RS23095 Protein ID WP_107131709.1
Coordinates 4618408..4618782 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5M00_RS23055 4615004..4615459 + 456 WP_000581504.1 hypothetical protein -
E5M00_RS23060 4615538..4615771 + 234 WP_001119729.1 DUF905 family protein -
E5M00_RS23070 4615871..4616689 + 819 WP_080029847.1 DUF945 domain-containing protein -
E5M00_RS23080 4616990..4617463 + 474 WP_021552431.1 antirestriction protein -
E5M00_RS23085 4617479..4617955 + 477 WP_021513354.1 RadC family protein -
E5M00_RS23090 4618024..4618245 + 222 WP_074418799.1 DUF987 domain-containing protein -
E5M00_RS23095 4618408..4618782 + 375 WP_107131709.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
E5M00_RS23100 4618829..4619206 + 378 WP_001094453.1 TA system toxin CbtA family protein Toxin
E5M00_RS23105 4619203..4619691 + 489 WP_074418798.1 hypothetical protein -
E5M00_RS23110 4619703..4619900 + 198 WP_000839244.1 DUF957 domain-containing protein -
E5M00_RS23115 4619985..4620833 + 849 WP_024249539.1 DUF4942 domain-containing protein -
E5M00_RS23120 4620892..4621095 - 204 WP_001545728.1 hypothetical protein -
E5M00_RS23125 4621105..4621755 - 651 WP_000056760.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
E5M00_RS23130 4621769..4622233 - 465 WP_000776505.1 PTS ascorbate transporter subunit IIA -
E5M00_RS23135 4622243..4622548 - 306 WP_000218362.1 PTS ascorbate transporter subunit IIB -
E5M00_RS23140 4622564..4623961 - 1398 WP_001351893.1 PTS ascorbate transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14181.04 Da        Isoelectric Point: 5.5831

>T123159 WP_001094453.1 NZ_CP038791:4618829-4619206 [Escherichia coli]
MNTLPDTHVRETSGCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

>T123159 NZ_CP038791:4618829-4619206 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13681.48 Da        Isoelectric Point: 5.0598

>AT123159 WP_107131709.1 NZ_CP038791:4618408-4618782 [Escherichia coli]
VSDALPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRADIRGRFSDADSYHLEQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT123159 NZ_CP038791:4618408-4618782 [Escherichia coli]
GTGTCAGACGCACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGATATCAGAGGCCGCT
TCAGCGACGCGGATTCGTACCACCTGGAGCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References