Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3872372..3873028 Replicon chromosome
Accession NZ_CP038662
Organism Serratia nematodiphila strain DH-S01

Toxin (Protein)


Gene name vapC Uniprot ID A0A086GBH4
Locus tag E5D60_RS18440 Protein ID WP_033632382.1
Coordinates 3872372..3872761 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086GBH3
Locus tag E5D60_RS18445 Protein ID WP_033632381.1
Coordinates 3872765..3873028 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5D60_RS18425 3868839..3870269 + 1431 WP_033632384.1 multidrug transporter subunit MdtD -
E5D60_RS18430 3870266..3871648 + 1383 WP_033632383.1 two-component system sensor histidine kinase BaeS -
E5D60_RS18435 3871648..3872364 + 717 WP_004941568.1 two-component system response regulator BaeR -
E5D60_RS18440 3872372..3872761 - 390 WP_033632382.1 type II toxin-antitoxin system VapC family toxin Toxin
E5D60_RS18445 3872765..3873028 - 264 WP_033632381.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E5D60_RS18450 3873366..3873704 + 339 WP_004941561.1 YegP family protein -
E5D60_RS18455 3873883..3875235 + 1353 WP_060560045.1 tRNA 5-hydroxyuridine modification protein YegQ -
E5D60_RS18460 3875703..3876608 + 906 WP_135638495.1 lipid kinase YegS -
E5D60_RS18465 3876869..3877918 + 1050 WP_015378749.1 class I fructose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14353.58 Da        Isoelectric Point: 8.4983

>T123112 WP_033632382.1 NZ_CP038662:c3872761-3872372 [Serratia nematodiphila]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRSKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKILGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T123112 NZ_CP038662:c3872761-3872372 [Serratia nematodiphila]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTTATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCGTTACGGTGTGGCTAAACGGCGGAGCAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGGGCAAACATGGAGAGAAAGGGCAAAATCCTGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10089.34 Da        Isoelectric Point: 4.6702

>AT123112 WP_033632381.1 NZ_CP038662:c3873028-3872765 [Serratia nematodiphila]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLNIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT123112 NZ_CP038662:c3873028-3872765 [Serratia nematodiphila]
ATGGAAAGGATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAACATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCCTTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086GBH4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GBH3

References