Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1751468..1751993 Replicon chromosome
Accession NZ_CP038662
Organism Serratia nematodiphila strain DH-S01

Toxin (Protein)


Gene name relE Uniprot ID A0A8B4GJ35
Locus tag E5D60_RS08315 Protein ID WP_033633469.1
Coordinates 1751468..1751752 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B4GIN1
Locus tag E5D60_RS08320 Protein ID WP_004928423.1
Coordinates 1751742..1751993 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5D60_RS08290 1746730..1747863 + 1134 WP_004938650.1 putrescine ABC transporter ATP-binding subunit PotG -
E5D60_RS08295 1747888..1748850 + 963 WP_033633472.1 putrescine ABC transporter permease PotH -
E5D60_RS08300 1748847..1749692 + 846 WP_004938644.1 putrescine ABC transporter permease PotI -
E5D60_RS08305 1749797..1750282 + 486 WP_050501266.1 YbjO family protein -
E5D60_RS08310 1750344..1751471 + 1128 WP_033633470.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
E5D60_RS08315 1751468..1751752 - 285 WP_033633469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E5D60_RS08320 1751742..1751993 - 252 WP_004928423.1 prevent-host-death protein Antitoxin
E5D60_RS08325 1752095..1752829 - 735 WP_033633468.1 arginine ABC transporter substrate-binding protein -
E5D60_RS08330 1753029..1753697 - 669 WP_004928418.1 arginine ABC transporter permease ArtM -
E5D60_RS08335 1753697..1754413 - 717 WP_004928413.1 arginine ABC transporter permease ArtQ -
E5D60_RS08340 1754423..1755154 - 732 WP_004928409.1 arginine ABC transporter substrate-binding protein -
E5D60_RS08345 1755187..1755915 - 729 WP_004928406.1 arginine ABC transporter ATP-binding protein ArtP -
E5D60_RS08350 1756178..1756720 - 543 WP_015377301.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10789.91 Da        Isoelectric Point: 10.6941

>T123100 WP_033633469.1 NZ_CP038662:c1751752-1751468 [Serratia nematodiphila]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T123100 NZ_CP038662:c1751752-1751468 [Serratia nematodiphila]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCGGTGCTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCTGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTATATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT123100 WP_004928423.1 NZ_CP038662:c1751993-1751742 [Serratia nematodiphila]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT123100 NZ_CP038662:c1751993-1751742 [Serratia nematodiphila]
ATGACGGTTCAACCCATTCTTGCCGACTCGGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAACCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCTCCGGAAACCTGGGAGGCGA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GJ35

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GIN1

References