Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 460672..461243 Replicon chromosome
Accession NZ_CP038662
Organism Serratia nematodiphila strain DH-S01

Toxin (Protein)


Gene name relE Uniprot ID A0A086G7I6
Locus tag E5D60_RS02160 Protein ID WP_033631648.1
Coordinates 460968..461243 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag E5D60_RS02155 Protein ID WP_013811307.1
Coordinates 460672..460959 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5D60_RS02130 456441..457526 - 1086 WP_135637732.1 carbon-phosphorus lyase complex subunit PhnI -
E5D60_RS02135 457526..458107 - 582 WP_135637733.1 phosphonate C-P lyase system protein PhnH -
E5D60_RS02140 458111..458554 - 444 WP_033631646.1 phosphonate C-P lyase system protein PhnG -
E5D60_RS02145 458555..459283 - 729 WP_046898001.1 phosphonate metabolism transcriptional regulator PhnF -
E5D60_RS02150 459511..460566 + 1056 WP_135637734.1 permease -
E5D60_RS02155 460672..460959 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E5D60_RS02160 460968..461243 + 276 WP_033631648.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
E5D60_RS02165 461249..461713 - 465 WP_033631649.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
E5D60_RS02170 461882..464020 - 2139 WP_033631650.1 anaerobic ribonucleoside-triphosphate reductase -
E5D60_RS02175 464265..465179 - 915 WP_033631651.1 LysR family transcriptional regulator -
E5D60_RS02180 465285..465809 + 525 WP_033631652.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10723.48 Da        Isoelectric Point: 8.4940

>T123097 WP_033631648.1 NZ_CP038662:460968-461243 [Serratia nematodiphila]
MRIEWDNAALRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLDHPELGKPWYGKARKLLVDKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

>T123097 NZ_CP038662:460968-461243 [Serratia nematodiphila]
ATGCGTATCGAATGGGATAATGCAGCGCTACGGGACAGGGAACGTATTTTTGAGTTTCTTTATATTTTCAATCCACAGGC
GGCAGTGCAGGCTGATAACGAGATAGATAAAGCGGTAAAGCGCCTGCTGGATCATCCTGAATTAGGTAAGCCTTGGTATG
GGAAGGCACGTAAGCTGCTAGTGGACAAGGCCTCCCTGTTGCTGGTGTATATCATCGTCGATGATGTTATTAAGGTTTTC
TCGATTGCCCACCAGCGCGAGAAATTTCCAAACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT123097 WP_013811307.1 NZ_CP038662:460672-460959 [Serratia nematodiphila]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp

>AT123097 NZ_CP038662:460672-460959 [Serratia nematodiphila]
ATGGAAAGTCGCATCCAGTTTCGCATCGAAGATGAAACCAAGCGTTTGGCGCAAAAGGCCGCGGAAGCTAAAGGAACGAC
ATTGAGTGAAGCCTGCCGCCGCTTGGCGGAGCAAATGGCTGATGAGCAACGGGCCGCGGAGGAGCACGAAAATTGGTTGA
AAGATAAGGTGGATGCAGCTTTTTCCCGTCTGCATGAGGGTAATGCTGTCTACCTTAGCCAACAAGAAGTAGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAATTAGAGCGAAATACGACCGAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086G7I6

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References