Detailed information of TA system TA123094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3623404..3624083
• Replicon: chromosome
• Accession: NZ_CP038644
• Organism: Acinetobacter baumannii strain ACN21

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: E5D09_RS17350
• Protein ID: WP_000838146.1
• Coordinates: 3623404..3623586 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: E5D09_RS17355
• Protein ID: WP_000966688.1
• Coordinates: 3623679..3624083 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5D09_RS17310	3618702..3619070	+	369	WP_025468552.1	hypothetical protein	-
E5D09_RS17315	3619072..3619470	+	399	WP_057078255.1	hypothetical protein	-
E5D09_RS17320	3619472..3619699	+	228	WP_057078256.1	hypothetical protein	-
E5D09_RS17325	3619814..3620167	+	354	WP_057078257.1	hypothetical protein	-
E5D09_RS17330	3620167..3621522	+	1356	WP_000002416.1	hypothetical protein	-
E5D09_RS17335	3621575..3622492	+	918	WP_000094253.1	hypothetical protein	-
E5D09_RS17340	3622563..3623078	+	516	WP_024616020.1	hypothetical protein	-
E5D09_RS17350	3623404..3623586	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
E5D09_RS17355	3623679..3624083	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E5D09_RS17360	3624182..3624862	+	681	WP_000721572.1	hypothetical protein	-
E5D09_RS17365	3624864..3625127	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	csuA/B / csuA / csuB / csuC / csuD / csuE / pgaB / pgaC / pgaD / plc	3325292..3628791	303499

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T123094 WP_000838146.1 NZ_CP038644:3623404-3623586 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T123094 NZ_CP038644:3623404-3623586 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT123094 WP_000966688.1 NZ_CP038644:3623679-3624083 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT123094 NZ_CP038644:3623679-3624083 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6