Detailed information of TA system TA123093

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2509259..2509912
• Replicon: chromosome
• Accession: NZ_CP038644
• Organism: Acinetobacter baumannii strain ACN21

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A9E9PBS3
• Locus tag: E5D09_RS12170
• Protein ID: WP_002096593.1
• Coordinates: 2509523..2509912 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2G8V6F0
• Locus tag: E5D09_RS12165
• Protein ID: WP_029424136.1
• Coordinates: 2509259..2509516 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5D09_RS12145	2504775..2505782	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
E5D09_RS12150	2505801..2506178	+	378	WP_001216380.1	50S ribosomal protein L17	-
E5D09_RS12155	2506360..2507850	+	1491	WP_000415132.1	NAD(P)/FAD-dependent oxidoreductase	-
E5D09_RS12160	2507899..2509071	-	1173	WP_001190550.1	acyl-CoA dehydrogenase family protein	-
E5D09_RS12165	2509259..2509516	+	258	WP_029424136.1	succinate dehydrogenase assembly factor 2	Antitoxin
E5D09_RS12170	2509523..2509912	+	390	WP_002096593.1	hypothetical protein	Toxin
E5D09_RS12175	2510682..2511767	+	1086	WP_000049106.1	hypothetical protein	-
E5D09_RS12180	2511845..2512411	+	567	WP_000651536.1	rhombosortase	-
E5D09_RS12185	2512599..2514794	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15677.99 Da
• Isoelectric Point: 10.3890

>T123093 WP_002096593.1 NZ_CP038644:2509523-2509912 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T123093 NZ_CP038644:2509523-2509912 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10360.85 Da
• Isoelectric Point: 4.4909

>AT123093 WP_029424136.1 NZ_CP038644:2509259-2509516 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADLAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
YYVHG

Nucleotide

• Length: 258 bp

>AT123093 NZ_CP038644:2509259-2509516 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCTGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
TACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2G8V6F0