Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 74610..75141 Replicon plasmid unnamed5
Accession NZ_CP038640
Organism Cupriavidus oxalaticus strain X32

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag E0W60_RS36850 Protein ID WP_011114071.1
Coordinates 74860..75141 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag E0W60_RS36845 Protein ID WP_011114070.1
Coordinates 74610..74873 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0W60_RS36800 69816..70580 - 765 WP_011114061.1 ParA family protein -
E0W60_RS36805 70577..70885 - 309 WP_011114062.1 KorA protein -
E0W60_RS36810 70992..71321 - 330 WP_011114064.1 DUF2761 domain-containing protein -
E0W60_RS36815 71323..71649 - 327 WP_011114065.1 hypothetical protein -
E0W60_RS36820 71858..72094 - 237 WP_011114066.1 stable inheritance protein KleA -
E0W60_RS36825 72252..72509 - 258 WP_011114067.1 hypothetical protein -
E0W60_RS36830 72526..73734 - 1209 WP_011114068.1 hypothetical protein -
E0W60_RS36835 73746..74009 - 264 WP_011296181.1 hypothetical protein -
E0W60_RS36840 74009..74437 - 429 WP_011114069.1 antirestriction protein -
E0W60_RS36845 74610..74873 + 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E0W60_RS36850 74860..75141 + 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
E0W60_RS36870 76462..78153 - 1692 WP_007180429.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..89459 89459
- flank IS/Tn - - 78297..81323 3026


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T123089 WP_011114071.1 NZ_CP038640:74860-75141 [Cupriavidus oxalaticus]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T123089 NZ_CP038640:74860-75141 [Cupriavidus oxalaticus]
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAAGGGCAGCACCGGGCCACGCTCGA
CGCCGACCTGGTGCCCGTCCTGGTCGCGCTCGCCGACGACCAGCCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAGGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCCTCGGCTCTCACTCCGAACTCGGCTTGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT123089 WP_011114070.1 NZ_CP038640:74610-74873 [Cupriavidus oxalaticus]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT123089 NZ_CP038640:74610-74873 [Cupriavidus oxalaticus]
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCCTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTGGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTCAACGATCTGATG
GCCGATCTGCATGCGGCAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References