Detailed information of TA system TA123088

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 183700..184267
• Replicon: plasmid unnamed1
• Accession: NZ_CP038636
• Organism: Cupriavidus oxalaticus strain X32

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E0W60_RS28885
• Protein ID: WP_135706445.1
• Coordinates: 183700..183984 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A069I8F4
• Locus tag: E0W60_RS28890
• Protein ID: WP_022540171.1
• Coordinates: 183971..184267 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0W60_RS28860	179390..179617	+	228	WP_135706442.1	hypothetical protein	-
E0W60_RS28865	179683..180594	-	912	WP_135706443.1	LysR family transcriptional regulator	-
E0W60_RS28870	180695..181867	+	1173	WP_135706444.1	pyridoxal-phosphate dependent enzyme	-
E0W60_RS28875	181894..182862	+	969	WP_135707072.1	tripartite tricarboxylate transporter substrate binding protein	-
E0W60_RS28880	183332..183787	+	456	WP_135707073.1	type II toxin-antitoxin system YoeB family toxin	-
E0W60_RS28885	183700..183984	-	285	WP_135706445.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E0W60_RS28890	183971..184267	-	297	WP_022540171.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E0W60_RS28895	184739..186202	-	1464	WP_135706446.1	patatin-like phospholipase family protein	-
E0W60_RS28900	186604..188406	-	1803	WP_135706447.1	sulfatase-like hydrolase/transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	katA	1..1192287	1192287

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-57)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10454.86 Da
• Isoelectric Point: 5.6705

>T123088 WP_135706445.1 NZ_CP038636:c183984-183700 [Cupriavidus oxalaticus]
VRAVEWTRWARADLLAIVDYISDDNPDAAQSLKDDLEAKAARLPEHPELYRAGRVAGTREMVVAANYLVVYAVDATSIRI
LRVLHAAQQWPSPG

Nucleotide

• Length: 285 bp

>T123088 NZ_CP038636:c183984-183700 [Cupriavidus oxalaticus]
GTGCGCGCGGTTGAATGGACGCGGTGGGCCAGGGCCGATCTTCTCGCCATCGTTGACTACATCTCGGATGATAATCCGGA
TGCGGCCCAGAGCCTGAAGGACGACCTCGAAGCGAAAGCGGCACGGCTGCCGGAACACCCCGAGCTCTACCGAGCCGGCC
GCGTCGCGGGCACGCGCGAGATGGTCGTGGCGGCCAACTACCTGGTCGTGTACGCCGTGGATGCCACCTCCATCCGGATC
CTGCGGGTACTCCATGCCGCGCAGCAATGGCCGTCGCCCGGTTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10796.35 Da
• Isoelectric Point: 7.3193

>AT123088 WP_022540171.1 NZ_CP038636:c184267-183971 [Cupriavidus oxalaticus]
MAHTSMLHIRVDDDLKARATQNLASVGLTVSDAVRILLTRIAKEGGLPPGLTTDPETYDAWFRAKVQQALTDPAPPLPHD
QVMDDVQALIDRKRRARG

Nucleotide

• Length: 297 bp

>AT123088 NZ_CP038636:c184267-183971 [Cupriavidus oxalaticus]
ATGGCGCATACTTCAATGTTGCACATCCGGGTGGACGACGACCTTAAAGCCCGGGCCACGCAAAACCTTGCCAGCGTCGG
GCTAACCGTGTCCGACGCAGTTCGCATCCTGTTGACACGGATCGCCAAGGAGGGCGGGCTGCCGCCCGGTCTGACGACGG
ATCCCGAGACCTATGATGCTTGGTTCCGCGCAAAGGTCCAGCAAGCGCTGACCGACCCGGCCCCGCCGCTCCCGCATGAC
CAGGTCATGGACGACGTTCAGGCGCTGATCGACCGGAAACGCCGTGCGCGCGGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A069I8F4