Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1794656..1796385 Replicon chromosome
Accession NZ_CP038635
Organism Cupriavidus oxalaticus strain X32

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag E0W60_RS19065 Protein ID WP_135705254.1
Coordinates 1795057..1796385 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag E0W60_RS19060 Protein ID WP_135705253.1
Coordinates 1794656..1795054 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0W60_RS19045 1790607..1791446 + 840 WP_135705250.1 YaiO family outer membrane beta-barrel protein -
E0W60_RS19050 1791449..1792255 + 807 WP_135705251.1 hypothetical protein -
E0W60_RS19055 1792833..1794413 + 1581 WP_135705252.1 isocitrate lyase -
E0W60_RS19060 1794656..1795054 + 399 WP_135705253.1 helix-turn-helix domain-containing protein Antitoxin
E0W60_RS19065 1795057..1796385 + 1329 WP_135705254.1 type II toxin-antitoxin system HipA family toxin Toxin
E0W60_RS19070 1796388..1796798 - 411 WP_135705255.1 DUF1801 domain-containing protein -
E0W60_RS19075 1796980..1800465 + 3486 WP_135705256.1 adenylate/guanylate cyclase domain-containing protein -
E0W60_RS19080 1800462..1801115 + 654 WP_135705257.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(157-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 48505.33 Da        Isoelectric Point: 8.4925

>T123087 WP_135705254.1 NZ_CP038635:1795057-1796385 [Cupriavidus oxalaticus]
MARGTQARRLDLWMNGLPVGHWETTPAGDRLAYREDWIADPQGRPLSLSLPFTPGNQPHRGPVVANYFDNLLPDSDAIRR
RIAARYRTGGTDAFALLAKLGRDCAGALQMLPPQEAPTALKRVQGRPLSETEIATLLHEATAEPVLGLREPIDDLRLSIA
GAQEKTALLRWGGHWLLPQGSTPTTHIFKLPMGLVGNMRADMRTSVENEWLCARIVAAFGLPVAACEIARFGDVKALVVE
RFDRKPSADGSWLLRLPQEDMCQATGTSALQKYESDGGPGIQQIADILSGSRSALSDRRNFFLAQIVFWLLAATDGHGKN
FSISHLPGSRYEATPLYDILSAHPIIGRGKNQVAPQRARLAMALHGKNSHYAIQEIQRRHWFAQGQRIGFSPDDVGSMLD
EVVSQTGRAIDAAASALPPEFPLDLADAIFDGMRRQQRRLAA

Download         Length: 1329 bp

>T123087 NZ_CP038635:1795057-1796385 [Cupriavidus oxalaticus]
ATGGCGCGCGGCACGCAGGCGAGGCGTCTCGATCTGTGGATGAACGGGTTGCCGGTGGGTCACTGGGAAACCACGCCCGC
CGGCGACCGGCTGGCCTATCGCGAGGACTGGATTGCCGACCCGCAAGGCCGGCCGCTGTCCCTGTCATTACCCTTTACGC
CGGGCAACCAGCCCCACCGCGGGCCCGTCGTCGCCAACTATTTCGACAACCTGCTGCCCGACAGCGATGCCATCAGGCGG
CGCATCGCGGCCCGGTACCGGACCGGCGGGACCGACGCCTTCGCGCTGCTGGCCAAGCTCGGCCGCGACTGTGCCGGCGC
CCTCCAGATGCTGCCGCCGCAGGAGGCACCGACGGCGTTGAAGCGCGTCCAGGGCCGCCCGCTGTCGGAGACCGAGATCG
CCACCCTGCTGCATGAGGCCACGGCCGAGCCCGTGCTCGGGCTGCGCGAGCCCATCGATGACCTGCGCCTGTCCATCGCC
GGCGCGCAGGAGAAGACCGCGCTGCTGCGCTGGGGCGGGCACTGGCTGTTGCCGCAAGGCAGTACGCCTACCACGCATAT
CTTCAAGCTGCCGATGGGACTGGTGGGCAATATGCGCGCCGACATGCGGACCTCGGTGGAAAACGAATGGCTCTGCGCCA
GGATCGTCGCCGCCTTTGGCCTGCCGGTCGCTGCCTGCGAGATCGCGCGCTTCGGGGATGTCAAGGCACTGGTGGTCGAA
CGCTTCGACCGCAAGCCTTCGGCCGACGGTTCCTGGCTGCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCCACCGGGAC
GTCGGCATTGCAGAAGTACGAGTCGGACGGCGGGCCCGGCATCCAGCAGATCGCCGACATCCTCTCCGGCTCGCGCTCGG
CGCTGTCCGATCGCCGCAACTTCTTCCTCGCGCAGATCGTGTTCTGGCTGCTTGCCGCCACTGATGGCCATGGCAAGAAC
TTCAGCATCAGCCATCTGCCGGGCAGCCGCTATGAAGCAACGCCGCTGTACGACATCCTGTCGGCGCATCCGATCATCGG
CAGGGGCAAGAACCAGGTGGCGCCGCAACGGGCCCGGCTGGCGATGGCGTTGCACGGCAAGAATTCGCACTACGCCATCC
AGGAGATCCAGCGGCGACACTGGTTTGCCCAGGGACAGCGCATCGGCTTCTCGCCCGACGACGTCGGGTCGATGCTCGAC
GAGGTCGTGTCGCAGACCGGCCGGGCCATCGACGCCGCCGCTTCCGCGCTGCCGCCGGAATTCCCCCTGGACCTGGCCGA
TGCGATCTTCGACGGCATGCGCCGGCAGCAGCGGCGCCTTGCTGCCTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14473.62 Da        Isoelectric Point: 11.1865

>AT123087 WP_135705253.1 NZ_CP038635:1794656-1795054 [Cupriavidus oxalaticus]
MQYPIHTLTQLRPILQGFRKSRGLTQARMAAYLGVRQQTYAELEANPAAASVERLFKALRVLGVEMVLSPAPDTQVSQVP
QVQPEPVQETSPASLPASKAARKATTEQPKKPAGGKASRAARKSTRPQREDW

Download         Length: 399 bp

>AT123087 NZ_CP038635:1794656-1795054 [Cupriavidus oxalaticus]
ATGCAATATCCCATCCATACCCTCACCCAGCTGCGGCCGATCCTGCAGGGCTTCAGGAAGTCCAGGGGCCTGACGCAGGC
CAGGATGGCGGCTTACCTGGGCGTCCGGCAGCAGACCTACGCCGAGCTGGAAGCCAACCCCGCCGCGGCCAGCGTCGAGC
GGCTGTTCAAGGCACTGCGCGTGCTCGGCGTGGAGATGGTGCTGTCCCCTGCCCCGGATACCCAGGTGTCCCAGGTGCCC
CAGGTGCAGCCGGAACCTGTGCAAGAGACAAGTCCCGCCTCCCTGCCGGCAAGCAAGGCTGCCCGCAAGGCAACAACGGA
ACAGCCGAAAAAGCCCGCTGGCGGCAAGGCAAGCCGCGCCGCCCGCAAGAGCACCAGGCCACAGCGGGAGGATTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References