Detailed information of TA system TA123086

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 682126..682691
• Replicon: chromosome
• Accession: NZ_CP038635
• Organism: Cupriavidus oxalaticus strain X32

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E0W60_RS13975
• Protein ID: WP_135704668.1
• Coordinates: 682320..682691 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: E0W60_RS13970
• Protein ID: WP_133093923.1
• Coordinates: 682126..682323 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0W60_RS13955	677820..678779	-	960	WP_135704664.1	formimidoylglutamase	-
E0W60_RS13960	678776..680074	-	1299	WP_133093921.1	MFS transporter	-
E0W60_RS13965	680183..681865	-	1683	WP_135704666.1	urocanate hydratase	-
E0W60_RS13970	682126..682323	+	198	WP_133093923.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
E0W60_RS13975	682320..682691	+	372	WP_135704668.1	type II toxin-antitoxin system VapC family toxin	Toxin
E0W60_RS13980	682742..683458	-	717	WP_135704670.1	histidine utilization repressor	-
E0W60_RS13985	683494..686883	-	3390	WP_135704672.1	diguanylate cyclase	-
E0W60_RS13990	687249..687623	+	375	WP_133094225.1	nuclear transport factor 2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13299.36 Da
• Isoelectric Point: 5.5599

>T123086 WP_135704668.1 NZ_CP038635:682320-682691 [Cupriavidus oxalaticus]
MILVDTSVWIDHLRTGDAALAALLDASRVLVHPFVIGEIALGSLRQRDEVLGALRDLPGAVVATDDEVDRMIDDQKLYGI
GIGYVDAHLLAATRLTPGSALWTRDRRLLALAERLGLAARPAH

Nucleotide

• Length: 372 bp

>T123086 NZ_CP038635:682320-682691 [Cupriavidus oxalaticus]
ATGATCCTGGTCGACACTTCGGTATGGATCGACCATCTGCGTACCGGCGACGCGGCACTAGCGGCTTTGCTCGACGCCAG
CCGGGTCCTGGTGCATCCGTTTGTGATCGGCGAGATCGCGCTGGGTAGCCTGCGGCAGCGGGACGAGGTGCTGGGCGCTT
TGCGTGATTTGCCAGGCGCCGTCGTGGCGACGGACGACGAAGTCGACCGGATGATCGATGACCAGAAGCTTTACGGGATA
GGGATTGGCTACGTGGATGCGCATCTGCTGGCCGCCACCCGATTGACGCCCGGCAGTGCGCTATGGACGCGGGATCGTCG
CCTGCTCGCGCTCGCCGAGCGTTTGGGGCTGGCCGCGCGGCCTGCGCATTAG

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7241.26 Da
• Isoelectric Point: 10.6625

>AT123086 WP_133093923.1 NZ_CP038635:682126-682323 [Cupriavidus oxalaticus]
MRTTLALDDDLLRKAQALTGLSEKSSLVREALRALIERESARRLSRLGGTEPDLESAPRRRPEPA

Nucleotide

• Length: 198 bp

>AT123086 NZ_CP038635:682126-682323 [Cupriavidus oxalaticus]
ATGCGTACCACGCTTGCCCTGGACGATGATTTGCTGCGCAAGGCCCAGGCCCTGACGGGCCTGTCAGAAAAATCCTCGCT
CGTGCGCGAAGCGCTACGGGCACTGATCGAGCGCGAAAGCGCGCGGCGCCTAAGCCGTCTCGGCGGTACCGAGCCCGACC
TGGAATCCGCGCCGCGCCGCCGCCCGGAGCCGGCATGA