Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1302231..1302827 Replicon chromosome
Accession NZ_CP038634
Organism Cupriavidus oxalaticus strain X32

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E0W60_RS05800 Protein ID WP_135703324.1
Coordinates 1302645..1302827 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E0W60_RS05795 Protein ID WP_135703323.1
Coordinates 1302231..1302620 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0W60_RS05770 1297801..1299030 + 1230 WP_135703320.1 NAD(P)/FAD-dependent oxidoreductase -
E0W60_RS05775 1299073..1299804 + 732 WP_133095610.1 3-oxoacyl-ACP reductase FabG -
E0W60_RS05780 1299825..1301039 + 1215 WP_135703321.1 cation:proton antiporter -
E0W60_RS05790 1301207..1302160 - 954 WP_135703322.1 prolyl aminopeptidase -
E0W60_RS05795 1302231..1302620 - 390 WP_135703323.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E0W60_RS05800 1302645..1302827 - 183 WP_135703324.1 type II toxin-antitoxin system HicA family toxin Toxin
E0W60_RS05805 1302956..1304281 - 1326 WP_135703325.1 argininosuccinate synthase -
E0W60_RS05810 1304585..1305748 + 1164 WP_135703326.1 CoA transferase -
E0W60_RS05815 1305790..1306761 + 972 WP_135703327.1 tripartite tricarboxylate transporter substrate binding protein -
E0W60_RS05820 1306785..1307561 + 777 WP_135703328.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6879.12 Da        Isoelectric Point: 11.7040

>T123085 WP_135703324.1 NZ_CP038634:c1302827-1302645 [Cupriavidus oxalaticus]
MKSADLIRQLMSDGWYLTHIVGSHHQFRHPTKPGKVTVPHPKKDLPLGTVRSILKQARLR

Download         Length: 183 bp

>T123085 NZ_CP038634:c1302827-1302645 [Cupriavidus oxalaticus]
ATGAAGAGCGCGGACCTGATCAGGCAACTGATGTCCGACGGCTGGTATTTGACGCACATCGTCGGATCGCACCATCAGTT
CAGGCACCCCACCAAACCAGGAAAGGTAACGGTGCCTCACCCGAAGAAAGACCTGCCACTCGGCACGGTGCGCAGCATCC
TCAAGCAGGCCCGCCTCCGGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14365.03 Da        Isoelectric Point: 4.8978

>AT123085 WP_135703323.1 NZ_CP038634:c1302620-1302231 [Cupriavidus oxalaticus]
MLYPVHIEPGDAKHAHGISFPDFPGCFSAADDWADIPANAQEAVEAHFADGEPIPEPSSPERWFHHPQYQGGIWMLVDID
LSRVNTRAVRVNISLPERLVQQIDDAAKSRHMSRSAFLALAAQHEMEQG

Download         Length: 390 bp

>AT123085 NZ_CP038634:c1302620-1302231 [Cupriavidus oxalaticus]
ATGCTATATCCCGTCCATATCGAGCCCGGCGACGCAAAGCACGCCCACGGCATCTCGTTTCCGGATTTCCCCGGATGCTT
TTCCGCTGCCGATGACTGGGCGGACATTCCAGCCAACGCGCAGGAGGCTGTCGAAGCCCACTTTGCCGACGGGGAGCCGA
TTCCCGAACCATCCAGTCCGGAGCGCTGGTTTCATCATCCGCAGTATCAGGGCGGCATCTGGATGCTGGTCGACATCGAC
TTGTCGCGCGTCAACACAAGAGCCGTACGGGTGAACATCAGCTTGCCAGAGCGCTTGGTCCAGCAAATCGATGATGCTGC
CAAAAGCCGGCATATGAGCCGATCGGCATTTCTCGCGCTGGCGGCACAGCACGAGATGGAACAAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References