Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1015157..1015800 Replicon chromosome
Accession NZ_CP038634
Organism Cupriavidus oxalaticus strain X32

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E0W60_RS04385 Protein ID WP_135703148.1
Coordinates 1015157..1015558 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E0W60_RS04390 Protein ID WP_133095853.1
Coordinates 1015558..1015800 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0W60_RS04370 1010489..1010974 + 486 WP_135703146.1 DM13 domain-containing protein -
E0W60_RS04375 1011111..1012181 - 1071 WP_135703147.1 porin -
E0W60_RS04380 1012500..1015139 + 2640 WP_133095851.1 transglycosylase domain-containing protein -
E0W60_RS04385 1015157..1015558 - 402 WP_135703148.1 type II toxin-antitoxin system VapC family toxin Toxin
E0W60_RS04390 1015558..1015800 - 243 WP_133095853.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E0W60_RS04395 1015893..1017226 - 1334 Protein_869 DUF1501 domain-containing protein -
E0W60_RS04400 1017254..1018837 - 1584 WP_135703970.1 DUF1800 domain-containing protein -
E0W60_RS04405 1018978..1019739 - 762 WP_133095856.1 NADPH-dependent F420 reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

SpoVT-AbrB domain

(13-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13914.97 Da        Isoelectric Point: 5.6870

>T123084 WP_135703148.1 NZ_CP038634:c1015558-1015157 [Cupriavidus oxalaticus]
MALFLLDTNIISDAIRNTRGACAARIEATDPDSLCTSIIVAAELRFGAAKNGSSALSQRVGQALAGLRVLPLGGDADHCY
GELRAALERKGTVIGANDMLIAAHALSLGAVLVTDNMGEFSRVNGLRCENWMA

Download         Length: 402 bp

>T123084 NZ_CP038634:c1015558-1015157 [Cupriavidus oxalaticus]
ATGGCCTTGTTCCTGCTCGACACCAATATCATTTCCGACGCCATTCGCAATACTCGTGGGGCTTGCGCGGCCCGGATCGA
AGCGACCGACCCCGATAGTCTCTGCACATCGATCATCGTCGCGGCCGAATTGCGCTTCGGCGCAGCAAAGAATGGCTCAT
CGGCGCTCAGCCAGCGTGTCGGCCAGGCACTGGCCGGCCTGCGCGTCCTGCCCCTCGGCGGTGACGCGGATCACTGCTAC
GGCGAGTTGCGTGCAGCACTGGAGCGCAAGGGCACAGTCATCGGAGCCAATGACATGCTGATTGCCGCGCATGCGCTCTC
GCTTGGGGCTGTTTTGGTCACCGACAACATGGGTGAATTTTCCCGCGTGAACGGACTGCGCTGCGAGAACTGGATGGCGT
AA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9253.42 Da        Isoelectric Point: 4.3637

>AT123084 WP_133095853.1 NZ_CP038634:c1015800-1015558 [Cupriavidus oxalaticus]
MTTTDEIRHVRLFRNGRNQAIRIPREFELPGDEAILRREGNHLIIEPVAATPLRALLSQWEPIDDDWPTIDDLPAEDVNL

Download         Length: 243 bp

>AT123084 NZ_CP038634:c1015800-1015558 [Cupriavidus oxalaticus]
ATGACGACAACCGACGAAATCCGCCATGTCAGGCTGTTCCGCAACGGTCGCAACCAGGCAATCCGCATCCCGCGCGAGTT
CGAGCTGCCCGGGGACGAGGCCATTCTTCGCCGCGAAGGCAACCACCTCATCATTGAGCCGGTCGCGGCCACGCCGTTGC
GGGCGCTGCTGTCGCAATGGGAGCCGATCGACGACGATTGGCCGACGATCGACGACTTGCCAGCCGAGGACGTCAATCTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References