Detailed information of TA system TA123084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1015157..1015800
• Replicon: chromosome
• Accession: NZ_CP038634
• Organism: Cupriavidus oxalaticus strain X32

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E0W60_RS04385
• Protein ID: WP_135703148.1
• Coordinates: 1015157..1015558 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: E0W60_RS04390
• Protein ID: WP_133095853.1
• Coordinates: 1015558..1015800 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0W60_RS04370	1010489..1010974	+	486	WP_135703146.1	DM13 domain-containing protein	-
E0W60_RS04375	1011111..1012181	-	1071	WP_135703147.1	porin	-
E0W60_RS04380	1012500..1015139	+	2640	WP_133095851.1	transglycosylase domain-containing protein	-
E0W60_RS04385	1015157..1015558	-	402	WP_135703148.1	type II toxin-antitoxin system VapC family toxin	Toxin
E0W60_RS04390	1015558..1015800	-	243	WP_133095853.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E0W60_RS04395	1015893..1017226	-	1334	Protein_869	DUF1501 domain-containing protein	-
E0W60_RS04400	1017254..1018837	-	1584	WP_135703970.1	DUF1800 domain-containing protein	-
E0W60_RS04405	1018978..1019739	-	762	WP_133095856.1	NADPH-dependent F420 reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

• SpoVT-AbrB domain (13-48)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 13914.97 Da
• Isoelectric Point: 5.6870

>T123084 WP_135703148.1 NZ_CP038634:c1015558-1015157 [Cupriavidus oxalaticus]
MALFLLDTNIISDAIRNTRGACAARIEATDPDSLCTSIIVAAELRFGAAKNGSSALSQRVGQALAGLRVLPLGGDADHCY
GELRAALERKGTVIGANDMLIAAHALSLGAVLVTDNMGEFSRVNGLRCENWMA

Nucleotide

• Length: 402 bp

>T123084 NZ_CP038634:c1015558-1015157 [Cupriavidus oxalaticus]
ATGGCCTTGTTCCTGCTCGACACCAATATCATTTCCGACGCCATTCGCAATACTCGTGGGGCTTGCGCGGCCCGGATCGA
AGCGACCGACCCCGATAGTCTCTGCACATCGATCATCGTCGCGGCCGAATTGCGCTTCGGCGCAGCAAAGAATGGCTCAT
CGGCGCTCAGCCAGCGTGTCGGCCAGGCACTGGCCGGCCTGCGCGTCCTGCCCCTCGGCGGTGACGCGGATCACTGCTAC
GGCGAGTTGCGTGCAGCACTGGAGCGCAAGGGCACAGTCATCGGAGCCAATGACATGCTGATTGCCGCGCATGCGCTCTC
GCTTGGGGCTGTTTTGGTCACCGACAACATGGGTGAATTTTCCCGCGTGAACGGACTGCGCTGCGAGAACTGGATGGCGT
AA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9253.42 Da
• Isoelectric Point: 4.3637

>AT123084 WP_133095853.1 NZ_CP038634:c1015800-1015558 [Cupriavidus oxalaticus]
MTTTDEIRHVRLFRNGRNQAIRIPREFELPGDEAILRREGNHLIIEPVAATPLRALLSQWEPIDDDWPTIDDLPAEDVNL

Nucleotide

• Length: 243 bp

>AT123084 NZ_CP038634:c1015800-1015558 [Cupriavidus oxalaticus]
ATGACGACAACCGACGAAATCCGCCATGTCAGGCTGTTCCGCAACGGTCGCAACCAGGCAATCCGCATCCCGCGCGAGTT
CGAGCTGCCCGGGGACGAGGCCATTCTTCGCCGCGAAGGCAACCACCTCATCATTGAGCCGGTCGCGGCCACGCCGTTGC
GGGCGCTGCTGTCGCAATGGGAGCCGATCGACGACGATTGGCCGACGATCGACGACTTGCCAGCCGAGGACGTCAATCTC
TGA