Detailed information of TA system TA123082

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 7897..8555
• Replicon: plasmid pArsFIN11
• Accession: NZ_CP038623
• Organism: Arsenophonus nasoniae strain FIN

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ArsFIN_RS25090
• Protein ID: WP_135679093.1
• Coordinates: 8379..8555 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ArsFIN_RS25085
• Protein ID: WP_135679091.1
• Coordinates: 7897..8313 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ArsFIN_RS25065	3372..4199	+	828	WP_135679086.1	hypothetical protein	-
ArsFIN_RS25070	4486..5478	+	993	WP_135679088.1	site-specific integrase	-
ArsFIN_RS25075	5740..6333	+	594	WP_135679090.1	hypothetical protein	-
ArsFIN_RS25080	6390..7766	+	1377	WP_135679158.1	phage terminase large subunit	-
ArsFIN_RS25085	7897..8313	-	417	WP_135679091.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ArsFIN_RS25090	8379..8555	-	177	WP_135679093.1	mRNA interferase	Toxin
ArsFIN_RS25095	8877..10079	-	1203	WP_135678014.1	IS91 family transposase	-
ArsFIN_RS25100	10089..10547	-	459	WP_135678353.1	hypothetical protein	-
ArsFIN_RS25105	10784..11980	+	1197	WP_167876792.1	DUF1073 domain-containing protein	-
ArsFIN_RS25110	11937..12815	+	879	WP_167876793.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..46250	46250

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (9-69)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6630.79 Da
• Isoelectric Point: 10.9137

>T123082 WP_135679093.1 NZ_CP038623:c8555-8379 [Arsenophonus nasoniae]
VKQSEFLKWLKSQGVKTENGKKHLRLYYKGKISHLPRHGSQELTTGLVEGVKKQLGLK

Nucleotide

• Length: 177 bp

>T123082 NZ_CP038623:c8555-8379 [Arsenophonus nasoniae]
GTGAAACAAAGCGAGTTTCTTAAGTGGTTGAAGTCACAAGGCGTTAAAACTGAAAACGGTAAAAAACATTTGAGACTCTA
CTACAAAGGTAAAATAAGCCATCTCCCAAGACACGGAAGTCAAGAGTTAACGACGGGATTAGTTGAAGGCGTAAAAAAAC
AGCTAGGCTTGAAATAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15774.23 Da
• Isoelectric Point: 6.0867

>AT123082 WP_135679091.1 NZ_CP038623:c8313-7897 [Arsenophonus nasoniae]
MFYPAKFTQEDNGYTVSFRDIKDAITCGSSFDEAMSMAEDIILCWIDVYFEKNEFVPMPSDSLYDYEHWVFLPDSIFAKV
LLHNEMLKAKISKAELARLMGTNSPEIQRILSARHKTKIDTISKALSKLGKHLTLSLA

Nucleotide

• Length: 417 bp

>AT123082 NZ_CP038623:c8313-7897 [Arsenophonus nasoniae]
ATGTTTTATCCAGCAAAATTTACCCAAGAAGATAATGGTTATACTGTCTCTTTTAGAGATATAAAAGACGCAATCACTTG
CGGTTCATCTTTCGATGAAGCCATGTCGATGGCGGAAGATATTATTTTGTGTTGGATAGATGTTTACTTTGAAAAAAATG
AATTTGTTCCTATGCCATCAGATAGTTTATATGATTATGAACATTGGGTATTTTTACCTGACAGCATTTTTGCTAAAGTT
TTATTACATAATGAAATGCTAAAAGCTAAAATTTCCAAAGCTGAGTTAGCTAGATTGATGGGTACAAATTCGCCAGAGAT
TCAAAGAATTTTATCTGCAAGACACAAAACGAAAATTGACACCATTAGTAAAGCATTATCAAAATTAGGTAAACATTTAA
CACTCTCTTTAGCGTGA