Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 35628..36264 Replicon plasmid pArsFIN8
Accession NZ_CP038620
Organism Arsenophonus nasoniae strain FIN

Toxin (Protein)


Gene name vapC Uniprot ID A0A4P7L2E3
Locus tag ArsFIN_RS23985 Protein ID WP_026823396.1
Coordinates 35860..36264 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4P7L1M6
Locus tag ArsFIN_RS23980 Protein ID WP_026823397.1
Coordinates 35628..35867 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ArsFIN_RS23955 31027..31788 - 762 WP_135677409.1 IS21-like element helper ATPase IstB -
ArsFIN_RS23960 31775..32830 - 1056 WP_135678962.1 IS21 family transposase -
ArsFIN_RS23970 34431..35120 + 690 WP_026823399.1 hypothetical protein -
ArsFIN_RS23975 35138..35521 + 384 WP_026823398.1 hypothetical protein -
ArsFIN_RS23980 35628..35867 + 240 WP_026823397.1 antitoxin Antitoxin
ArsFIN_RS23985 35860..36264 + 405 WP_026823396.1 type II toxin-antitoxin system VapC family toxin Toxin
ArsFIN_RS23990 36709..37674 + 966 WP_051297076.1 tyrosine-type recombinase/integrase -
ArsFIN_RS26810 37671..37829 + 159 WP_155846998.1 hypothetical protein -
ArsFIN_RS26815 37879..38055 + 177 WP_167876777.1 hypothetical protein -
ArsFIN_RS23995 38057..38491 + 435 WP_026823394.1 hypothetical protein -
ArsFIN_RS24000 38540..39295 + 756 WP_135678964.1 signal peptidase I -
ArsFIN_RS24005 39298..39891 + 594 WP_026823392.1 hypothetical protein -
ArsFIN_RS24010 39869..40237 + 369 WP_026823391.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120926 120926
- flank IS/Tn - - 33665..33979 314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15217.49 Da        Isoelectric Point: 8.5036

>T123081 WP_026823396.1 NZ_CP038620:35860-36264 [Arsenophonus nasoniae]
MIKYLLDTNIVIFTIKRKPVSLLPKFNQHTNQLAISAITFAELIFGAEKSMNSAKNLATVNDFVSRLTVLPYDEQAAFHY
GDIKANFEKKEKPIGDNDLHIAAHARSKGLVVVTNNTREFERVEGLRIEDWTQL

Download         Length: 405 bp

>T123081 NZ_CP038620:35860-36264 [Arsenophonus nasoniae]
TTGATTAAATATTTACTCGATACAAATATCGTTATATTTACGATTAAACGGAAACCAGTATCGCTATTGCCTAAATTCAA
TCAACATACTAATCAACTGGCTATATCTGCGATAACGTTTGCAGAGCTAATTTTTGGTGCTGAAAAAAGCATGAACTCTG
CTAAAAATTTAGCAACAGTTAATGACTTTGTTTCTCGATTAACCGTTTTACCTTATGACGAACAAGCTGCATTTCATTAC
GGTGATATAAAGGCTAATTTTGAAAAAAAAGAAAAACCAATTGGTGACAATGACTTACATATAGCCGCTCATGCCAGAAG
CAAAGGGCTTGTTGTAGTAACAAACAACACTAGAGAGTTTGAAAGAGTTGAGGGGTTAAGAATCGAAGACTGGACACAAT
TATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9195.27 Da        Isoelectric Point: 4.7420

>AT123081 WP_026823397.1 NZ_CP038620:35628-35867 [Arsenophonus nasoniae]
MIQQGKVFMSNRTQNVRLPADTRFPDDVKDVIVRVKGKERIISPVQNAWDSFFLSEQSVTDDFLSNRTEQITSERESFD

Download         Length: 240 bp

>AT123081 NZ_CP038620:35628-35867 [Arsenophonus nasoniae]
ATGATACAGCAAGGTAAAGTTTTTATGAGCAATCGAACTCAAAATGTTCGACTGCCAGCAGACACACGTTTTCCTGATGA
TGTTAAAGACGTTATTGTTCGAGTGAAGGGTAAAGAACGCATCATTTCTCCTGTACAAAACGCATGGGATAGTTTTTTCT
TATCAGAGCAGTCTGTAACGGATGATTTTTTATCAAACAGAACTGAACAGATAACAAGCGAAAGAGAATCCTTTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7L2E3

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7L1M6

References