Detailed information of TA system TA123080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 13765..14287
• Replicon: plasmid pArsFIN6
• Accession: NZ_CP038618
• Organism: Arsenophonus nasoniae strain FIN

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ArsFIN_RS22795
• Protein ID: WP_135678791.1
• Coordinates: 13765..14046 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ArsFIN_RS22800
• Protein ID: WP_135678793.1
• Coordinates: 14036..14287 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ArsFIN_RS22760	9198..10166	+	969	WP_135678441.1	DUF2184 domain-containing protein	-
ArsFIN_RS22765	10268..10567	+	300	WP_135678443.1	hypothetical protein	-
ArsFIN_RS22770	10603..10989	+	387	WP_135678445.1	DUF4054 domain-containing protein	-
ArsFIN_RS22775	10989..11264	+	276	WP_135678788.1	hypothetical protein	-
ArsFIN_RS22780	11401..12603	-	1203	WP_135678014.1	IS91 family transposase	-
ArsFIN_RS22785	12613..13071	-	459	WP_135678330.1	hypothetical protein	-
ArsFIN_RS22790	13403..13768	+	366	WP_135678789.1	hypothetical protein	-
ArsFIN_RS22795	13765..14046	-	282	WP_135678791.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ArsFIN_RS22800	14036..14287	-	252	WP_135678793.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ArsFIN_RS22805	14353..14886	+	534	WP_135678795.1	hypothetical protein	-
ArsFIN_RS22810	14876..15568	+	693	WP_135678797.1	DUF3383 family protein	-
ArsFIN_RS22815	15705..16907	-	1203	WP_135678014.1	IS91 family transposase	-
ArsFIN_RS22820	16917..17375	-	459	WP_135678771.1	hypothetical protein	-
ArsFIN_RS22825	17513..18352	+	840	WP_135678799.1	DUF3383 family protein	-
ArsFIN_RS22830	18362..18646	+	285	WP_167876761.1	hypothetical protein	-
ArsFIN_RS22835	18759..19217	+	459	WP_135678317.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..61872	61872

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11085.10 Da
• Isoelectric Point: 10.6178

>T123080 WP_135678791.1 NZ_CP038618:c14046-13765 [Arsenophonus nasoniae]
MSYSIEFEKRALKEWKKLAHPIREQFKKKLVKVLEYPHIKSAQLHGHQYRYKIKLKSSGYRLVYEVNDNKLLLLVIAVGI
RANNEVYQLASKR

Nucleotide

• Length: 282 bp

>T123080 NZ_CP038618:c14046-13765 [Arsenophonus nasoniae]
ATGAGCTATAGTATTGAATTTGAAAAACGCGCATTAAAAGAGTGGAAAAAATTAGCTCATCCAATACGTGAGCAATTTAA
GAAAAAGTTAGTTAAAGTTCTGGAATATCCACATATAAAATCTGCACAATTACACGGACATCAATATCGGTACAAAATCA
AACTAAAATCATCTGGATATCGATTAGTTTATGAAGTAAACGATAATAAACTTTTATTGCTCGTTATTGCCGTGGGAATA
AGAGCTAATAACGAAGTGTATCAGCTAGCAAGCAAACGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9343.49 Da
• Isoelectric Point: 3.8960

>AT123080 WP_135678793.1 NZ_CP038618:c14287-14036 [Arsenophonus nasoniae]
MTYEILTSTVASITDLKRNPMGTVAEAEGNAVAILNRNEPAFYCVPPDLYAYFQELAEDTELNRIADERMKNPEFVSVNI
DEL

Nucleotide

• Length: 252 bp

>AT123080 NZ_CP038618:c14287-14036 [Arsenophonus nasoniae]
ATGACTTATGAAATATTAACGAGTACGGTTGCAAGCATTACCGATTTAAAACGCAATCCAATGGGTACAGTCGCTGAAGC
AGAAGGAAATGCAGTTGCCATCCTTAACCGAAATGAACCAGCTTTTTACTGCGTACCACCTGATTTATATGCTTATTTTC
AAGAATTGGCAGAAGATACCGAGCTTAATCGTATTGCTGATGAACGCATGAAAAACCCTGAGTTTGTGAGTGTCAATATT
GATGAGCTATAG