Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 870212..870689 Replicon chromosome
Accession NZ_CP038612
Organism Staphylococcus aureus strain O268

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SaO268_RS04400 Protein ID WP_000052076.1
Coordinates 870212..870400 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SaO268_RS04405 Protein ID WP_001059690.1
Coordinates 870429..870689 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO268_RS04370 866199..866720 + 522 WP_000824478.1 hypothetical protein -
SaO268_RS04375 867061..867747 + 687 WP_001641381.1 thermonuclease family protein -
SaO268_RS04380 868104..868304 + 201 WP_001059082.1 cold-shock protein -
SaO268_RS04385 868803..869021 - 219 WP_000005880.1 hypothetical protein -
SaO268_RS04390 869083..869367 - 285 WP_001004402.1 hypothetical protein -
SaO268_RS04395 869455..870024 - 570 WP_001106650.1 hypothetical protein -
SaO268_RS04400 870212..870400 - 189 WP_000052076.1 hypothetical protein Toxin
SaO268_RS04405 870429..870689 - 261 WP_001059690.1 hypothetical protein Antitoxin
SaO268_RS04410 871030..871233 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SaO268_RS04415 871230..871466 - 237 WP_000368687.1 hypothetical protein -
SaO268_RS04420 871691..872272 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
SaO268_RS04425 872345..872962 - 618 WP_135830959.1 LysE/ArgO family amino acid transporter -
SaO268_RS04430 873118..873612 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
SaO268_RS04435 874011..874433 - 423 WP_000974462.1 organic hydroperoxide resistance protein -
SaO268_RS04440 874581..875297 + 717 WP_000150023.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T123063 WP_000052076.1 NZ_CP038612:c870400-870212 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T123063 NZ_CP038612:c870400-870212 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT123063 WP_001059690.1 NZ_CP038612:c870689-870429 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT123063 NZ_CP038612:c870689-870429 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References